Acute Myeloid Leukemia: From Biology to Clinical Practices Through Development and Pre-Clinical Therapeutics.
CAR T cells
acute myeloid leukemia
clinical trials
immunotherapies
management
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2020
2020
Historique:
received:
28
08
2020
accepted:
02
11
2020
entrez:
28
12
2020
pubmed:
29
12
2020
medline:
29
12
2020
Statut:
epublish
Résumé
Recent studies have provided several insights into acute myeloid leukemia. Studies based on molecular biology have identified eight functional mutations involved in leukemogenesis, including driver and passenger mutations. Insight into Leukemia stem cells (LSCs) and assessment of cell surface markers have enabled characterization of LSCs from hematopoietic stem and progenitor cells. Clonal evolution has been described as having an effect similar to that of microenvironment alterations. Such biological findings have enabled the development of new targeted drugs, including drug inhibitors and monoclonal antibodies with blockage functions. Some recently approved targeted drugs have resulted in new therapeutic strategies that enhance standard intensive chemotherapy regimens as well as supportive care regimens. Besides the progress made in adoptive immunotherapy, since allogenic hematopoietic stem cell transplantation enabled the development of new T-cell transfer therapies, such as chimeric antigen receptor T-cell and transgenic TCR T-cell engineering, new promising strategies that are investigated.
Identifiants
pubmed: 33363031
doi: 10.3389/fonc.2020.599933
pmc: PMC7757414
doi:
Types de publication
Systematic Review
Langues
eng
Pagination
599933Informations de copyright
Copyright © 2020 Roussel, Daguindau, Berceanu, Desbrosses, Warda, Neto da Rocha, Trad, Deconinck, Deschamps and Ferrand.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Leukemia. 2020 Apr;34(4):1182-1186
pubmed: 31796915
Leukemia. 2020 Mar;34(3):682-696
pubmed: 31919472
Oncotarget. 2016 May 31;7(22):32532-42
pubmed: 27081038
Sci Rep. 2018 Dec 3;8(1):17544
pubmed: 30510164
Blood. 2020 Feb 13;135(7):463-471
pubmed: 31841594
Cancer Cell. 2013 Jul 8;24(1):90-104
pubmed: 23845443
Br J Haematol. 2019 Mar;184(5):782-787
pubmed: 30467839
J Exp Med. 2016 Jul 25;213(8):1513-35
pubmed: 27377587
Blood. 2017 Dec 7;130(23):2469-2474
pubmed: 29051180
Cancer Cell. 2018 Sep 10;34(3):499-512.e9
pubmed: 30205049
Invest New Drugs. 2020 Apr;38(2):340-349
pubmed: 31102119
Cancer Cell. 2014 Feb 10;25(2):226-42
pubmed: 24525236
Haematologica. 2015 Jul;100(7):859-69
pubmed: 26130513
Blood. 2013 Jun 6;121(23):4655-62
pubmed: 23613521
Front Oncol. 2018 May 18;8:152
pubmed: 29868474
Best Pract Res Clin Haematol. 2019 Jun;32(2):127-133
pubmed: 31203994
Haematologica. 2017 May;102(5):865-873
pubmed: 28126965
Bone Marrow Transplant. 2014 Feb;49(2):168-73
pubmed: 23892326
JAMA Oncol. 2018 Sep 1;4(9):1245-1253
pubmed: 30003233
J Exp Med. 2016 Apr 4;213(4):483-97
pubmed: 26951332
Nat Med. 2006 Oct;12(10):1167-74
pubmed: 16998484
Leukemia. 2018 Jun;32(6):1317-1326
pubmed: 29515236
Lancet. 2009 May 2;373(9674):1550-61
pubmed: 19282026
Front Oncol. 2019 Mar 27;9:192
pubmed: 30972300
Cell. 2018 May 31;173(6):1439-1453.e19
pubmed: 29856956
Blood. 2014 Jul 17;124(3):344-53
pubmed: 24914142
Front Immunol. 2020 Feb 14;11:121
pubmed: 32117272
Blood. 2017 Oct 12;130(15):1713-1721
pubmed: 28830889
Blood. 2007 Oct 1;110(7):2659-66
pubmed: 17609428
Blood. 2009 Oct 29;114(18):3909-16
pubmed: 19710498
Br J Haematol. 2021 Mar;192(6):1026-1030
pubmed: 32458446
Blood. 2016 Jul 14;128(2):253-64
pubmed: 27257182
Mol Ther. 2013 Nov;21(11):2122-9
pubmed: 23831595
Leukemia. 2017 Dec;31(12):2799-2806
pubmed: 28546581
Blood Adv. 2019 Sep 10;3(17):2525-2536
pubmed: 31471322
Hemasphere. 2019 Jan 30;3(1):e152
pubmed: 31723801
Haematologica. 2020 Jun;105(6):1507-1516
pubmed: 32241850
Cancer Cell. 2011 Jul 12;20(1):53-65
pubmed: 21741596
Blood. 2019 Apr 11;133(15):1630-1643
pubmed: 30803991
Front Oncol. 2019 Nov 07;9:1162
pubmed: 31781488
Blood Adv. 2020 Jan 28;4(2):274-286
pubmed: 31968078
Cell Stem Cell. 2016 Jul 7;19(1):23-37
pubmed: 27374788
Am J Hematol. 2018 Oct;93(10):1236-1244
pubmed: 30058714
Blood. 2017 Mar 23;129(12):1577-1585
pubmed: 28159741
Oncotarget. 2016 Jul 12;7(28):43281-43294
pubmed: 27248327
Mol Ther. 2017 Aug 2;25(8):1933-1945
pubmed: 28479045
Lancet Oncol. 2015 Dec;16(16):1691-9
pubmed: 26549589
Int Immunol. 2018 Jul 24;30(8):375-383
pubmed: 29868798
Cell Stem Cell. 2014 Mar 6;14(3):329-41
pubmed: 24440599
Leukemia. 2011 Jul;25(7):1147-52
pubmed: 21494260
Leuk Res. 2007 Jan;31(1):33-7
pubmed: 16806467
Hum Gene Ther. 2018 May;29(5):626-639
pubmed: 29409351
Oncotarget. 2013 May;4(5):715-28
pubmed: 23651669
Cell. 2012 Jul 20;150(2):264-78
pubmed: 22817890
Blood Adv. 2020 Jan 28;4(2):239-251
pubmed: 31945158
Blood. 2017 Apr 27;129(17):2384-2394
pubmed: 28122740
Nat Med. 2019 Apr;25(4):603-611
pubmed: 30911134
Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10786-91
pubmed: 26261316
Front Immunol. 2018 Jun 14;9:1357
pubmed: 29963052
J Clin Oncol. 2019 Jul 20;37(21):1785-1789
pubmed: 31112477
Haematologica. 2019 Apr;104(4):710-716
pubmed: 30409796
N Engl J Med. 2016 Nov 24;375(21):2023-2036
pubmed: 27959731
Nat Biotechnol. 2018 Oct;36(9):847-856
pubmed: 30102295
Oncoimmunology. 2018 Jul 30;7(9):e1472195
pubmed: 30228941
Blood. 2020 Jun 11;135(24):2137-2145
pubmed: 32219442
Blood. 2020 Jan 9;135(2):85-96
pubmed: 31765470
Blood. 2013 May 2;121(18):3709-13
pubmed: 23479569
Blood. 2010 Jan 21;115(3):453-74
pubmed: 19880497
Blood. 2012 Jun 28;119(26):6198-208
pubmed: 22286199
Front Immunol. 2014 Oct 13;5:483
pubmed: 25352844
Best Pract Res Clin Haematol. 2019 Jun;32(2):145-153
pubmed: 31203996
Nat Cell Biol. 2016 Jun;18(6):607-18
pubmed: 27111842
Blood. 2014 Apr 10;123(15):2343-54
pubmed: 24596416
Front Oncol. 2020 Feb 28;10:262
pubmed: 32185132
Clin Cancer Res. 2009 May 15;15(10):3325-32
pubmed: 19417016
PLoS One. 2019 Jul 10;14(7):e0219547
pubmed: 31291378
Nat Commun. 2020 Feb 5;11(1):579
pubmed: 32024830
Best Pract Res Clin Haematol. 2019 Jun;32(2):116-126
pubmed: 31203993
N Engl J Med. 2019 Oct 31;381(18):1728-1740
pubmed: 31665578
Expert Rev Anticancer Ther. 2019 May;19(5):393-404
pubmed: 30887841
Leukemia. 2011 Apr;25(4):567-74
pubmed: 21252983
JAMA. 2009 Jun 10;301(22):2349-61
pubmed: 19509382
Mol Cell Proteomics. 2007 Sep;6(9):1551-9
pubmed: 17507369
Blood. 2018 Jan 4;131(1):108-120
pubmed: 29051183
J Clin Oncol. 2018 Sep 10;36(26):2684-2692
pubmed: 30024784
Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2548-53
pubmed: 24550281
Nat Commun. 2019 Mar 25;10(1):1065
pubmed: 30911002
Nat Immunol. 2019 Sep;20(9):1138-1149
pubmed: 31427775
J Clin Oncol. 2019 May 20;37(15):1277-1284
pubmed: 30892988
JAMA Oncol. 2019 Dec 1;5(12):1739-1748
pubmed: 31621796
Leuk Res. 2005 Oct;29(10):1109-16
pubmed: 16095690
Blood. 2019 Aug 29;134(9):741-745
pubmed: 31243041
Cancer Res. 2019 Feb 1;79(3):663-675
pubmed: 30514753
Blood. 2018 Dec 6;132(23):2484-2494
pubmed: 30275109
Blood. 2016 Dec 29;128(26):3113-3124
pubmed: 27802968
Blood. 2013 Oct 31;122(18):3138-48
pubmed: 24030378
Nat Commun. 2014 Apr 09;5:3600
pubmed: 24714562
Leukemia. 2020 Jan;34(1):87-99
pubmed: 31363160
Leukemia. 2014 Jun;28(6):1280-8
pubmed: 24270737
Nat Med. 2019 Jul;25(7):1064-1072
pubmed: 31235963
Nat Rev Mol Cell Biol. 2019 May;20(5):303-320
pubmed: 30745579
J Clin Oncol. 2017 Mar 20;35(9):934-946
pubmed: 28297624
Nat Med. 2012 Mar 11;18(4):605-11
pubmed: 22406747
Blood. 2013 Aug 8;122(6):1017-25
pubmed: 23801631
J Clin Med. 2019 Feb 06;8(2):
pubmed: 30736352
Blood. 2016 Jan 7;127(1):71-8
pubmed: 26660428
N Engl J Med. 2016 Aug 25;375(8):740-53
pubmed: 27292104
Leukemia. 2018 May;32(5):1168-1179
pubmed: 29472720
Haematologica. 2020 Jan 31;105(2):407-413
pubmed: 31101756
Bone Marrow Transplant. 2019 Dec;54(12):2004-2012
pubmed: 31152148
Blood. 2017 Oct 12;130(15):1693-1698
pubmed: 28874349
Blood. 2017 Mar 23;129(12):1617-1626
pubmed: 28159735
Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11008-13
pubmed: 17576927
Leukemia. 2020 Mar;34(3):671-681
pubmed: 31915366
Am J Hematol. 2018 Oct;93(10):1267-1291
pubmed: 30328165
Immunol Rev. 2008 Dec;226:10-8
pubmed: 19161412
Blood Rev. 2020 Sep;43:100654
pubmed: 32029263
Bone Marrow Transplant. 2003 Nov;32(10):969-78
pubmed: 14595384
Hemasphere. 2019 Mar 29;3(2):e191
pubmed: 31723828
Immunotherapy. 2019 Sep;11(13):1117-1128
pubmed: 31361167
Cancer Discov. 2019 Mar;9(3):370-383
pubmed: 30409776
Blood. 2005 Oct 15;106(8):2912-9
pubmed: 15994282
N Engl J Med. 2013 May 30;368(22):2059-74
pubmed: 23634996
Blood. 2017 Aug 10;130(6):722-731
pubmed: 28588020
Cell Stem Cell. 2009 Jul 2;5(1):31-42
pubmed: 19570512
Hematology Am Soc Hematol Educ Program. 2016 Dec 2;2016(1):348-355
pubmed: 27913501
Front Oncol. 2020 May 06;10:697
pubmed: 32435621
Cytotherapy. 2014 Nov;16(11):1453-1466
pubmed: 24856895
Cells. 2019 Apr 03;8(4):
pubmed: 30987263
N Engl J Med. 2016 Jun 9;374(23):2209-2221
pubmed: 27276561
Haematologica. 2019 Mar;104(3):e100-e103
pubmed: 30190344
Blood. 2013 Apr 11;121(15):2854-63
pubmed: 23355537
Haematologica. 2018 Oct;103(10):1579-1581
pubmed: 30270203
Blood. 2013 Jan 3;121(1):170-7
pubmed: 23115274
Best Pract Res Clin Haematol. 2019 Dec;32(4):101104
pubmed: 31779970
Blood. 2016 Jan 7;127(1):53-61
pubmed: 26660429
Blood. 2016 Apr 21;127(16):2018-27
pubmed: 26834243
Cancer Discov. 2019 Feb;9(2):158
pubmed: 30523001
J Clin Oncol. 2010 Oct 1;28(28):4339-45
pubmed: 20733134
Blood. 2017 Apr 27;129(17):2395-2407
pubmed: 28246194
Science. 2016 Mar 25;351(6280):1463-9
pubmed: 26940869
Nature. 2018 Oct;562(7728):526-531
pubmed: 30333627
Leukemia. 2016 Jun;30(6):1344-54
pubmed: 26857467
Haematologica. 2018 Aug;103(8):1317-1328
pubmed: 29748438
Blood. 2019 Feb 14;133(7):676-687
pubmed: 30510081
Biol Blood Marrow Transplant. 2020 May;26(5):884-892
pubmed: 31891815
Br J Cancer. 2015 Jan 20;112(2):232-7
pubmed: 25290089
Blood Adv. 2020 Jan 28;4(2):296-300
pubmed: 31971998
Blood Adv. 2020 Mar 10;4(5):970-982
pubmed: 32150613
Eur J Haematol. 2014 Mar;92(3):195-203
pubmed: 24175978
Blood. 2016 May 19;127(20):2391-405
pubmed: 27069254
Hemasphere. 2018 Mar 01;2(2):e34
pubmed: 31723762
N Engl J Med. 2015 Sep 17;373(12):1136-52
pubmed: 26376137
J Exp Med. 2018 Jun 4;215(6):1709-1727
pubmed: 29773641
Cancer Res. 2009 Oct 15;69(20):8127-32
pubmed: 19808971
Cell Stem Cell. 2015 Oct 1;17(4):412-21
pubmed: 26387756
Cancer. 2005 Oct 1;104(7):1442-52
pubmed: 16116598
Blood. 2017 Nov 30;130(22):2373-2376
pubmed: 29021230
Blood Adv. 2018 Nov 27;2(22):3404-3410
pubmed: 30482770
N Engl J Med. 2019 Jan 3;380(1):45-56
pubmed: 30501490
Blood. 2019 Jan 3;133(1):7-17
pubmed: 30361262
Biol Blood Marrow Transplant. 2020 Mar;26(3):463-471
pubmed: 31562960
Cancer Discov. 2017 Oct;7(10):1136-1153
pubmed: 28729405
Oncogene. 2011 Mar 3;30(9):1009-19
pubmed: 21076471
Front Oncol. 2019 Sep 19;9:917
pubmed: 31616632
Adv Exp Med Biol. 2017;995:73-95
pubmed: 28321813
Am J Hematol. 2018 Sep;93(9):1136-1141
pubmed: 30028037
Ann Oncol. 2020 Jun;31(6):697-712
pubmed: 32171751
Front Immunol. 2020 Feb 21;11:276
pubmed: 32153583
J Hematol Oncol. 2018 Jan 10;11(1):7
pubmed: 29316944
J Clin Oncol. 2021 Jan 1;39(1):57-65
pubmed: 33119479
Leukemia. 2018 Nov;32(11):2374-2387
pubmed: 29743719
Blood. 2017 Mar 23;129(12):1636-1645
pubmed: 28049642
Cancer Res. 2006 Oct 1;66(19):9339-44
pubmed: 16990346
Leukemia. 2019 Feb;33(2):379-389
pubmed: 30555165
Cancer Cell. 2011 Jan 18;19(1):138-52
pubmed: 21251617
Nat Rev Immunol. 2020 Nov;20(11):651-668
pubmed: 32433532
Blood Rev. 2019 May;35:18-31
pubmed: 30826141
Blood. 2017 Jan 26;129(4):424-447
pubmed: 27895058
Blood. 2017 Aug 10;130(6):732-741
pubmed: 28588019
Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1117-1122
pubmed: 28096371
Cancer Discov. 2017 May;7(5):478-493
pubmed: 28193778
N Engl J Med. 2011 Nov 3;365(18):1673-83
pubmed: 22047558
Lancet Oncol. 2019 Jul;20(7):984-997
pubmed: 31175001
Nat Med. 2018 Aug;24(8):1192-1203
pubmed: 29988124
Cancer Immunol Res. 2019 Jan;7(1):100-112
pubmed: 30396908
J Clin Invest. 2019 Feb 1;129(2):774-785
pubmed: 30640174
Lancet. 2012 Apr 21;379(9825):1508-16
pubmed: 22482940
Cancer Cell. 2017 Oct 9;32(4):506-519.e5
pubmed: 29017060
N Engl J Med. 2005 Jan 20;352(3):254-66
pubmed: 15659725
Blood. 2013 Nov 21;122(22):3616-27; quiz 3699
pubmed: 24030381
Sci Transl Med. 2018 Dec 5;10(470):
pubmed: 30518613
J Clin Oncol. 2017 Apr 10;35(11):1154-1161
pubmed: 28380315
Blood. 2017 Apr 20;129(16):2330-2332
pubmed: 28153826
Lancet Haematol. 2020 Feb;7(2):e157-e167
pubmed: 32004485
Blood. 2012 Apr 12;119(15):3440-9
pubmed: 22371883
Cancer Cell. 2017 Sep 11;32(3):324-341.e6
pubmed: 28870739
Cell Stem Cell. 2014 Mar 6;14(3):275-91
pubmed: 24607403
Blood. 2003 Aug 15;102(4):1389-96
pubmed: 12714493
Cell. 2009 Jul 23;138(2):286-99
pubmed: 19632179
J Clin Oncol. 2013 Sep 20;31(27):3360-8
pubmed: 23940227
Sci Transl Med. 2019 Sep 4;11(508):
pubmed: 31484791
Front Immunol. 2019 Dec 20;10:3004
pubmed: 31921218
Clin Cancer Res. 2021 Jun 1;27(11):3141-3153
pubmed: 33531429
Lancet Haematol. 2016 Apr;3(4):e186-95
pubmed: 27063977
Leukemia. 2020 Jul;34(7):1907-1923
pubmed: 32047237
Leukemia. 2014 Dec;28(12):2355-66
pubmed: 24736212
Br J Haematol. 2020 Jan;188(1):147-158
pubmed: 31782805
N Engl J Med. 2018 Jun 21;378(25):2386-2398
pubmed: 29860938
J Hematol Oncol. 2016 Jul 27;9(1):61
pubmed: 27465508
Nat Commun. 2018 Jan 16;9(1):248
pubmed: 29339738
PLoS One. 2016 Aug 22;11(8):e0159477
pubmed: 27548616
Eur J Immunol. 2013 Mar;43(3):747-57
pubmed: 23175469
Blood Adv. 2018 Feb 13;2(3):224-234
pubmed: 29386195
N Engl J Med. 2018 Feb 1;378(5):449-459
pubmed: 29385376
J Exp Med. 2016 Mar 7;213(3):415-31
pubmed: 26903243
Leukemia. 2020 Oct;34(10):2688-2703
pubmed: 32358567
N Engl J Med. 2016 Jul 14;375(2):143-53
pubmed: 27410923
N Engl J Med. 2017 Dec 28;377(26):2531-2544
pubmed: 29226797
Nat Rev Clin Oncol. 2020 Mar;17(3):147-167
pubmed: 31848460
Blood. 2009 Sep 24;114(13):2733-43
pubmed: 19638619
Nat Rev Cancer. 2020 Mar;20(3):158-173
pubmed: 31907378
Cancers (Basel). 2019 Sep 12;11(9):
pubmed: 31547472
Leukemia. 2015 Aug;29(8):1637-47
pubmed: 25721896
Cancer Cell. 2019 Nov 11;36(5):471-482
pubmed: 31715131
J Clin Oncol. 2020 Feb 20;38(6):623-632
pubmed: 31851556
Haematologica. 2018 Aug;103(8):1288-1297
pubmed: 29773600
Biol Blood Marrow Transplant. 2019 Jul;25(7):1407-1415
pubmed: 30871978
Best Pract Res Clin Haematol. 2019 Dec;32(4):101109
pubmed: 31779972
Lancet Oncol. 2014 Aug;15(9):986-96
pubmed: 25008258
Blood. 2012 Aug 9;120(6):1290-8
pubmed: 22723552
Blood. 2016 Dec 8;128(23):2683-2693
pubmed: 27621309
Nat Med. 2018 Jun;24(6):739-748
pubmed: 29808007
N Engl J Med. 2020 Aug 13;383(7):617-629
pubmed: 32786187
Lancet Oncol. 2017 Oct;18(10):1317-1326
pubmed: 28844816
Nat Rev Immunol. 2018 Oct;18(10):635-647
pubmed: 30057419
Leukemia. 2016 Aug;30(8):1708-15
pubmed: 27063596
Oncoimmunology. 2020 Feb 17;9(1):1727078
pubmed: 32117593
Clin Cancer Res. 2017 Nov 1;23(21):6430-6440
pubmed: 28765326
Front Oncol. 2018 Jun 13;8:213
pubmed: 29951373
N Engl J Med. 2018 Dec 13;379(24):2330-2341
pubmed: 30380364
Expert Opin Ther Targets. 2018 Jul;22(7):563-565
pubmed: 29889568
Blood Adv. 2020 Jan 28;4(2):367-379
pubmed: 31985806
Mol Ther. 2017 Sep 6;25(9):2202-2213
pubmed: 28676343
Cell Stem Cell. 2010 Dec 3;7(6):708-17
pubmed: 21112565
N Engl J Med. 2017 Aug 3;377(5):454-464
pubmed: 28644114
Blood. 2017 Nov 2;130(18):1985-1994
pubmed: 28860210
Blood. 2020 Mar 5;135(10):713-723
pubmed: 31951650
Nature. 2012 Jan 11;481(7382):506-10
pubmed: 22237025
Bone Marrow Transplant. 2020 Jun;55(6):1114-1125
pubmed: 31996792
Blood. 2018 Mar 22;131(12):1275-1291
pubmed: 29330221