Maternal and Fetal Outcomes of Pregnancy in Nephrotic Syndrome Due to Primary Glomerulonephritis.
focal and segmental glomerulosclerosis
membranoproliferative glomerulonephritis
membranous nephropathy
minimal change disease
nephrotic syndrome
pregnancy
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2020
2020
Historique:
received:
17
05
2020
accepted:
12
11
2020
entrez:
28
12
2020
pubmed:
29
12
2020
medline:
29
12
2020
Statut:
epublish
Résumé
Chronic kidney disease (CKD) affects 3% of pregnancies, impacting on maternal and fetal outcomes, and at the same time, a recurrent question in nephrology regards gestation impact on kidney function. Observational studies stated that CKD stage, pre-existent hypertension, and proteinuria are the main predictors of possible complications, such as maternal CKD progression, maternal or fetal death, prematurity, small for gestational age (SGA) newborn, or admission to the neonatal intensive care unit. In this regard, given the prominence of proteinuria among other risk factors, we focused on primary nephrotic syndrome in pregnancy, which accounts for 0.028% of cases, and its impact on materno-fetal outcomes and kidney survival. Data extracted from literature are scattered because of the small cohorts investigated in each trial. However, they showed different outcomes for each glomerular disease, with membranous nephropathy (MN) having a better maternal and fetal prognosis than focal and segmental glomerulosclerosis (FSGS), membranoproliferative glomerulonephritis (MPGN), or minimal change disease (MCD). Nephrotic syndrome does not have to discourage women to undertake a pregnancy, but the correct management may include a specific evaluation of risk factors and follow-up for adverse materno-fetal events and/or maternal kidney disease progression.
Identifiants
pubmed: 33363180
doi: 10.3389/fmed.2020.563094
pmc: PMC7758435
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
563094Informations de copyright
Copyright © 2020 Siligato, Gembillo, Cernaro, Torre, Salvo, Granese and Santoro.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Nephron. 1969;6(4):498-525
pubmed: 5351517
Clin Nephrol. 1988 Apr;29(4):185-92
pubmed: 3155363
J Clin Med. 2018 Dec 15;7(12):
pubmed: 30558290
Am J Kidney Dis. 1991 Feb;17(2):116-22
pubmed: 1992651
Nutrients. 2017 Jul 19;9(7):
pubmed: 28753930
BMJ. 2011 Oct 18;343:d5931
pubmed: 22010128
Obstet Gynecol. 2013 Nov;122(5):1122-31
pubmed: 24150027
Clin Nephrol. 1987 Aug;28(2):56-64
pubmed: 3308231
Am J Med. 1979 Jan;66(1):82-90
pubmed: 420255
Diabetologia. 2014 May;57(5):1082-3
pubmed: 24526252
Am J Nephrol. 2017;45(5):442-451
pubmed: 28445873
Kidney Int. 2017 Jun;91(6):1464-1472
pubmed: 28233609
Am J Obstet Gynecol. 1985 Nov 1;153(5):508-14
pubmed: 4061512
Pregnancy Hypertens. 2018 Jul;13:65-71
pubmed: 30177074
J Pharm Sci. 2001 Oct;90(10):1583-92
pubmed: 11745716
J Am Soc Nephrol. 2015 Aug;26(8):2011-22
pubmed: 25766536
Nephron. 2002 May;91(1):21-4
pubmed: 12021515
BMC Nephrol. 2019 Jan 23;20(1):24
pubmed: 30674290
Am J Obstet Gynecol. 2015 Mar;212(3):337.e1-14
pubmed: 25265405
Expert Opin Pharmacother. 2015;16(12):1793-803
pubmed: 26155946
Blood. 2011 Feb 3;117(5):1499-506
pubmed: 21098742
Br Med J. 1969 Feb 1;1(5639):276-80
pubmed: 5762644
Nephron. 1984;36(2):101-5
pubmed: 6694775
Kidney Int. 1980 Aug;18(2):192-206
pubmed: 7441987
BMJ. 2008 Jan 26;336(7637):211-5
pubmed: 18219043
Pregnancy Hypertens. 2018 Oct;14:265-272
pubmed: 29567337
Fetal Diagn Ther. 2012;31(3):141-6
pubmed: 22441437
Pediatr Cardiol. 2015 Oct;36(7):1442-51
pubmed: 25951814
Am J Kidney Dis. 1987 Apr;9(4):328-33
pubmed: 3578269
Am J Kidney Dis. 2016 May;67(5):775-8
pubmed: 26744127
Am J Nephrol. 2020;51(4):304-317
pubmed: 32097941
N Engl J Med. 2006 Jun 8;354(23):2443-51
pubmed: 16760444
Kidney Int. 1986 Dec;30(6):914-9
pubmed: 3820941
Am J Kidney Dis. 2020 Oct;76(4):586-589
pubmed: 32093980
Obstet Gynecol. 2017 Jan;129(1):174-184
pubmed: 27926639
Br J Anaesth. 2010 Mar;104(3):276-84
pubmed: 20100698
J Clin Med. 2019 Jan 20;8(1):
pubmed: 30669543
Nat Rev Cardiol. 2011 Nov 22;9(1):7-8
pubmed: 22105671
Ren Fail. 1996 Jan;18(1):121-9
pubmed: 8820509
J Nephrol. 2016 Jun;29(3):277-303
pubmed: 26988973