Intrinsic Exercise Capacity and Mitochondrial DNA Lead to Opposing Vascular-Associated Risks.
intrinsic exercise capacity
mitochondria
vascular physiology
Journal
Function (Oxford, England)
ISSN: 2633-8823
Titre abrégé: Function (Oxf)
Pays: England
ID NLM: 101770668
Informations de publication
Date de publication:
2021
2021
Historique:
received:
11
05
2020
revised:
30
10
2020
accepted:
02
11
2020
entrez:
28
12
2020
pubmed:
29
12
2020
medline:
29
12
2020
Statut:
ppublish
Résumé
Exercise capacity is a strong predictor of all-cause morbidity and mortality in humans. However, the associated hemodynamic traits that link this valuable indicator to its subsequent disease risks are numerable. Additionally, exercise capacity has a substantial heritable component and genome-wide screening indicates a vast amount of nuclear and mitochondrial DNA (mtDNA) markers are significantly associated with traits of physical performance. A long-term selection experiment in rats confirms a divide for cardiovascular risks between low- and high-capacity runners (LCR and HCR, respectively), equipping us with a preclinical animal model to uncover new mechanisms. Here, we evaluated the LCR and HCR rat model system for differences in vascular function at the arterial resistance level. Consistent with the known divide between health and disease, we observed that LCR rats present with resistance artery and perivascular adipose tissue dysfunction compared to HCR rats that mimic qualities important for health, including improved vascular relaxation. Uniquely, we show by generating conplastic strains, which LCR males with mtDNA of female HCR (LCR-mt
Identifiants
pubmed: 33363281
doi: 10.1093/function/zqaa029
pii: zqaa029
pmc: PMC7749784
doi:
Substances chimiques
DNA, Mitochondrial
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Pagination
zqaa029Subventions
Organisme : NHLBI NIH HHS
ID : K99 HL151889
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL143082
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL151889
Pays : United States
Organisme : NIGMS NIH HHS
ID : R00 GM118885
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA219144
Pays : United States
Organisme : NIH HHS
ID : P40 OD021331
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of American Physiological Society.
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