Incidence of
GCK
HNF1A
MODY
South Africa
diabetes mellitus
monogenic diabetes
Journal
The application of clinical genetics
ISSN: 1178-704X
Titre abrégé: Appl Clin Genet
Pays: New Zealand
ID NLM: 101579789
Informations de publication
Date de publication:
2020
2020
Historique:
received:
15
09
2020
accepted:
06
11
2020
entrez:
28
12
2020
pubmed:
29
12
2020
medline:
29
12
2020
Statut:
epublish
Résumé
Maturity-onset diabetes of the young (MODY) is the result of single gene variants. To date, fourteen different MODY subtypes have been described. Variants in genes coding for glucokinase ( Study participants were recruited (1643 in total, 407 males, 1236 females) and underwent anthropometric tests. Thereafter, blood was collected, and real-time PCR was used to screen for specific variants in Ninety-seven individuals (5.9%) were identified with a specific In total, 6.6% of the study population expressed MODY variants. To our knowledge, we are the first to report on MODY incidence in Africa. This research provides the basis for MODY incidence studies in South Africa, as well as data on non-Caucasian populations.
Sections du résumé
BACKGROUND AND AIM
OBJECTIVE
Maturity-onset diabetes of the young (MODY) is the result of single gene variants. To date, fourteen different MODY subtypes have been described. Variants in genes coding for glucokinase (
METHODS
METHODS
Study participants were recruited (1643 in total, 407 males, 1236 females) and underwent anthropometric tests. Thereafter, blood was collected, and real-time PCR was used to screen for specific variants in
RESULTS
RESULTS
Ninety-seven individuals (5.9%) were identified with a specific
CONCLUSION
CONCLUSIONS
In total, 6.6% of the study population expressed MODY variants. To our knowledge, we are the first to report on MODY incidence in Africa. This research provides the basis for MODY incidence studies in South Africa, as well as data on non-Caucasian populations.
Identifiants
pubmed: 33363396
doi: 10.2147/TACG.S281872
pii: 281872
pmc: PMC7754620
doi:
Types de publication
Journal Article
Langues
eng
Pagination
209-219Informations de copyright
© 2020 Matsha et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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