Function and Dysfunction of Complement Factor H During Formation of Lipid-Rich Deposits.
Alzheimer Disease
/ genetics
Animals
Atherosclerosis
/ genetics
Complement Factor H
/ chemistry
Complement Pathway, Alternative
Glomerulonephritis
/ genetics
Humans
Inflammation
/ genetics
Lipid Metabolism
Macular Degeneration
/ genetics
Polymorphism, Genetic
Protein Conformation
Signal Transduction
Structure-Activity Relationship
C-reactive protein
HDL
adiponectin
amyloid-beta- protein
apoE
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
29
09
2020
accepted:
09
11
2020
entrez:
28
12
2020
pubmed:
29
12
2020
medline:
23
6
2021
Statut:
epublish
Résumé
Complement-mediated inflammation or dysregulation in lipid metabolism are associated with the pathogenesis of several diseases. These include age-related macular degeneration (AMD), C3 glomerulonephritis (C3GN), dense deposit disease (DDD), atherosclerosis, and Alzheimer's disease (AD). In all these diseases, formation of characteristic lipid-rich deposits is evident. Here, we will discuss molecular mechanisms whereby dysfunction of complement, and especially of its key regulator factor H, could be involved in lipid accumulation and related inflammation. The genetic associations to factor H polymorphisms, the role of factor H in the resolution of inflammation in lipid-rich deposits, modification of macrophage functions, and complement-mediated clearance of apoptotic and damaged cells indicate that the function of factor H is crucial in limiting inflammation in these diseases.
Identifiants
pubmed: 33363547
doi: 10.3389/fimmu.2020.611830
pmc: PMC7753009
doi:
Substances chimiques
CFH protein, human
0
Complement Factor H
80295-65-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
611830Informations de copyright
Copyright © 2020 Meri and Haapasalo.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Am J Hypertens. 2008 May;21(5):533-8
pubmed: 18292760
J Neuroinflammation. 2011 Jan 13;8(1):3
pubmed: 21232086
Clin Interv Aging. 2008;3(2):341-9
pubmed: 18686755
Neurobiol Aging. 2010 Jan;31(1):165-6
pubmed: 18433936
Lipids Health Dis. 2018 Jan 4;17(1):3
pubmed: 29301530
Alzheimer Dis Assoc Disord. 2005 Apr-Jun;19(2):55-66
pubmed: 15942322
J Neurosci. 2011 May 11;31(19):7049-59
pubmed: 21562267
Science. 2005 Apr 15;308(5720):419-21
pubmed: 15761120
J Immunol. 1999 Oct 1;163(7):3957-62
pubmed: 10490997
Clin Chim Acta. 1998 Apr 27;272(2):197-207
pubmed: 9641360
Kidney Int. 2009 May;75(9):952-60
pubmed: 19177158
Proc Natl Acad Sci U S A. 2005 May 17;102(20):7227-32
pubmed: 15870199
Science. 2005 Apr 15;308(5720):385-9
pubmed: 15761122
J Neuroinflammation. 2017 Mar 6;14(1):48
pubmed: 28264694
J Exp Med. 1978 Mar 1;147(3):730-44
pubmed: 273062
Trends Cardiovasc Med. 2001 Apr-May;11(3-4):142-7
pubmed: 11686004
Circ Cardiovasc Genet. 2017 Dec;10(6):
pubmed: 29212897
Pediatr Nephrol. 1999 Apr;13(3):233-6
pubmed: 10353412
Arterioscler Thromb Vasc Biol. 2003 Apr 1;23(4):630-6
pubmed: 12615690
Cell Death Differ. 2009 Dec;16(12):1630-40
pubmed: 19680263
J Clin Invest. 1996 Jul 1;98(1):1-2
pubmed: 8690779
Eye (Lond). 2001 Jun;15(Pt 3):390-5
pubmed: 11450763
Nature. 2017 Jan 26;541(7638):481-487
pubmed: 28099414
Diabetes. 2010 Jan;59(1):200-9
pubmed: 19833879
J Immunol. 2015 May 15;194(10):4963-73
pubmed: 25855355
Circulation. 2010 Nov 9;122(19):1948-56
pubmed: 20974996
Am J Med Genet B Neuropsychiatr Genet. 2008 Sep 5;147B(6):720-6
pubmed: 18163432
Nat Genet. 2013 Apr;45(4):433-9, 439e1-2
pubmed: 23455636
Front Immunol. 2018 Nov 21;9:2701
pubmed: 30519244
Am J Pathol. 1994 Mar;144(3):538-48
pubmed: 8129039
J Neuropathol Exp Neurol. 1997 Apr;56(4):376-81
pubmed: 9100668
Mayo Clin Proc. 2013 Nov;88(11):1284-93
pubmed: 24182705
Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18277-82
pubmed: 21969589
Science. 2016 May 6;352(6286):712-716
pubmed: 27033548
Neurosurgery. 2006 Nov;59(5):1069-76; discussion 1076-7
pubmed: 17016232
Front Immunol. 2017 May 16;8:545
pubmed: 28559893
Science. 1996 Jan 19;271(5247):348-50
pubmed: 8553069
Sci Rep. 2015 Aug 27;5:13489
pubmed: 26311128
J Exp Med. 1993 Jun 1;177(6):1827-31
pubmed: 8496694
Proc Natl Acad Sci U S A. 1979 Nov;76(11):5867-71
pubmed: 293688
Immunol Res. 2016 Feb;64(1):1-13
pubmed: 26091721
J Neuroimmunol. 2010 Dec 15;229(1-2):63-72
pubmed: 20674043
Cell Mol Immunol. 2020 Apr;17(4):313-322
pubmed: 32152553
Annu Rev Immunol. 2010;28:157-83
pubmed: 19968561
Eur J Immunol. 2003 Apr;33(4):962-9
pubmed: 12672062
Obes Res. 2003 Jun;11(6):699-708
pubmed: 12805391
J Cell Sci. 2010 Oct 1;123(Pt 19):3347-56
pubmed: 20826457
Mol Immunol. 2014 Oct;61(2):118-125
pubmed: 25034031
J Immunol. 2012 Aug 15;189(4):1858-67
pubmed: 22786770
J Exp Med. 2000 Nov 6;192(9):1353-64
pubmed: 11067883
J Immunol. 1977 Sep;119(3):812-7
pubmed: 894027
Virchows Arch B Cell Pathol Incl Mol Pathol. 1989;56(4):259-62
pubmed: 2565620
Cell Tissue Res. 2011 Jan;343(1):237-49
pubmed: 20683616
Biochem Biophys Res Commun. 2005 Apr 22;329(4):1208-16
pubmed: 15766555
N Engl J Med. 2001 Apr 5;344(14):1058-66
pubmed: 11287977
J Immunol. 1981 May;126(5):1820-5
pubmed: 7217669
Nat Med. 2019 Mar;25(3):496-506
pubmed: 30692699
J Biol Chem. 2014 Feb 14;289(7):4295-306
pubmed: 24344133
J Am Soc Nephrol. 2014 Nov;25(11):2425-33
pubmed: 24722444
J Immunol. 1999 Oct 15;163(8):4590-6
pubmed: 10510403
FEBS Lett. 2016 Aug;590(15):2418-34
pubmed: 27393384
J Mol Biol. 2006 Sep 1;361(5):932-44
pubmed: 16890957
Pathology. 2019 Feb;51(2):165-176
pubmed: 30598326
PLoS One. 2017 Mar 8;12(3):e0172675
pubmed: 28273167
J Biol Chem. 1995 Nov 10;270(45):26746-9
pubmed: 7592907
Am J Hum Genet. 1998 Jul;63(1):200-6
pubmed: 9634502
Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2897-902
pubmed: 21285368
Am J Pathol. 2003 Feb;162(2):413-25
pubmed: 12547700
Hum Mol Genet. 2013 Aug 15;22(16):3381-93
pubmed: 23620142
J Biol Chem. 1992 Jun 25;267(18):12736-41
pubmed: 1618777
Neurobiol Aging. 2001 Nov-Dec;22(6):843-8
pubmed: 11754991
Kidney Int. 2013 Dec;84(6):1079-89
pubmed: 24172683
Annu Rev Pathol. 2006;1:297-329
pubmed: 18039117
J Immunol. 2007 Mar 15;178(6):3831-6
pubmed: 17339482
J Exp Med. 1981 Sep 1;154(3):856-67
pubmed: 6912277
J Alzheimers Dis. 2014;42 Suppl 3:S163-6
pubmed: 24898654
Front Immunol. 2019 Aug 02;10:1750
pubmed: 31428091
Atherosclerosis. 2010 Nov;213(1):184-90
pubmed: 20708732
Science. 2005 Apr 15;308(5720):421-4
pubmed: 15761121
Prog Neurobiol. 2003 Aug;70(6):463-72
pubmed: 14568360
Am J Epidemiol. 1995 Aug 15;142(4):404-9
pubmed: 7625405
Am J Cardiol. 2002 Aug 15;90(4):404-8
pubmed: 12161231
Proc Natl Acad Sci U S A. 1990 May;87(10):3982-6
pubmed: 1692629
Nature. 2011 Oct 05;478(7367):76-81
pubmed: 21979047
J Biol Chem. 2015 Nov 27;290(48):28977-87
pubmed: 26468283
J Clin Invest. 1995 Jun;95(6):2611-9
pubmed: 7769103
Int J Mol Sci. 2019 Nov 29;20(23):
pubmed: 31795454
Circulation. 2009 Aug 25;120(8):699-708
pubmed: 19667236
Lancet. 1997 Jan 18;349(9046):151-4
pubmed: 9111537
Science. 1996 Apr 5;272(5258):50-3
pubmed: 8600536
J Biol Chem. 2014 Mar 28;289(13):9113-20
pubmed: 24550392
J Exp Med. 1992 Apr 1;175(4):939-50
pubmed: 1532415
Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13757-62
pubmed: 22875704
J Med Genet. 2006 Jul;43(7):582-9
pubmed: 16299065
Neurology. 1993 Aug;43(8):1467-72
pubmed: 8350998
Circulation. 2003 Oct 28;108(17):2107-12
pubmed: 14530200
Nat Rev Nephrol. 2019 Mar;15(3):129-143
pubmed: 30692664
Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8913-8
pubmed: 22615372
Free Radic Biol Med. 2013 Sep;62:157-169
pubmed: 23044265
Immunity. 2017 Feb 21;46(2):261-272
pubmed: 28228282
J Immunol. 1993 Nov 15;151(10):5545-53
pubmed: 8228245
Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13043-8
pubmed: 12244213
N Engl J Med. 1986 Aug 21;315(8):488-95
pubmed: 2942776
PLoS One. 2013 Nov 14;8(11):e79908
pubmed: 24244577
Nat Med. 2001 Jan;7(1):53-8
pubmed: 11135616
Front Immunol. 2018 Apr 19;9:808
pubmed: 29725335
J Neuroinflammation. 2011 Jan 15;8(1):4
pubmed: 21235806