Amyloid fibril formation is suppressed in microgravity.
Amyloid fibrils
Amyloidosis
Aβ, amyloid β
Aβ42
DMSO, dimethyl sulfoxide
FSB, 1-fluoro-2,5-bis[(E)-3-carboxy-4-hydroxystyryl]benzene
Insulin
Microgravity
PBS, phosphate-buffered saline
TTR
TTR, transthyretin
TTRwt, wild-type transthyretin
ThT, thioflavin T
Journal
Biochemistry and biophysics reports
ISSN: 2405-5808
Titre abrégé: Biochem Biophys Rep
Pays: Netherlands
ID NLM: 101660999
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
29
07
2020
revised:
27
11
2020
accepted:
09
12
2020
entrez:
28
12
2020
pubmed:
29
12
2020
medline:
29
12
2020
Statut:
epublish
Résumé
In the future, humans may live in space because of global pollution and weather fluctuations. In microgravity, convection does not occur, which may change the amyloidogenicity of proteins. However, the effect of gravity on amyloid fibril formation is unclear and remains to be elucidated. Here, we analyzed the effect of microgravity on amyloid fibril formation of amyloidogenic proteins including insulin, amyloid β
Identifiants
pubmed: 33364446
doi: 10.1016/j.bbrep.2020.100875
pii: S2405-5808(20)30185-0
pmc: PMC7750487
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100875Informations de copyright
© 2020 The Authors.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest relevant to the content of this article.
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