Intravenous ketamine for long term anesthesia in rats.
Anesthesia
Biological sciences
ERG
Electroretinogram
Ketamine
Laboratory medicine
Neuroscience
Ophthalmology
Physiology
Rat
Retina
Xylazine
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
26
08
2020
revised:
15
10
2020
accepted:
04
12
2020
entrez:
28
12
2020
pubmed:
29
12
2020
medline:
29
12
2020
Statut:
epublish
Résumé
Ketamine/xylazine anesthesia has been used primarily for short term procedures in animals, but two prior reports used intravenous ketamine/xylazine for experiments taking many hours. However, there is a discrepancy about the appropriate dose, which is resolved here. Adult Long-Evans rats were used for recording from the retina. Doses of Ketamine/xylazine were adjusted to minimize anesthetic in terminal experiments lasting 10 h. An allometric relation was fitted to the resulting data on doses as a function of body weight, and compared to prior work. The allometric relationship between the continuously infused specific dose and weight was: dose = 9.13 (weight)
Identifiants
pubmed: 33367124
doi: 10.1016/j.heliyon.2020.e05686
pii: S2405-8440(20)32529-9
pmc: PMC7749388
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e05686Informations de copyright
© 2020 The Authors.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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