Structure and regulation of coronavirus genomes: state-of-the-art and novel insights from SARS-CoV-2 studies.
RNA structure
SARS-CoV-2
coronavirus
Journal
Biochemical Society transactions
ISSN: 1470-8752
Titre abrégé: Biochem Soc Trans
Pays: England
ID NLM: 7506897
Informations de publication
Date de publication:
26 02 2021
26 02 2021
Historique:
received:
06
11
2020
revised:
08
12
2020
accepted:
10
12
2020
pubmed:
29
12
2020
medline:
23
3
2021
entrez:
28
12
2020
Statut:
ppublish
Résumé
Coronaviruses (CoV) are positive-sense single-stranded RNA viruses, harboring the largest viral RNA genomes known to date. Apart from the primary sequence encoding for all the viral proteins needed for the generation of new viral particles, certain regions of CoV genomes are known to fold into stable structures, controlling several aspects of CoV life cycle, from the regulation of the discontinuous transcription of subgenomic mRNAs, to the packaging of the genome into new virions. Here we review the current knowledge on CoV RNA structures, discussing it in light of the most recent discoveries made possible by analyses of the SARS-CoV-2 genome.
Identifiants
pubmed: 33367597
pii: 227424
doi: 10.1042/BST20200670
pmc: PMC7925004
doi:
Substances chimiques
RNA, Ribosomal
0
RNA, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
341-352Informations de copyright
© 2020 The Author(s).
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