Mass-spectrometry analysis of the human pineal proteome during night and day and in autism.
antioxidant
autism spectrum disorders
chaperon proteins
circadian rhythm
energy production
mass spectrometry
pineal gland
Journal
Journal of pineal research
ISSN: 1600-079X
Titre abrégé: J Pineal Res
Pays: England
ID NLM: 8504412
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
revised:
16
12
2020
received:
16
08
2020
accepted:
18
12
2020
pubmed:
29
12
2020
medline:
11
11
2021
entrez:
28
12
2020
Statut:
ppublish
Résumé
The human pineal gland regulates day-night dynamics of multiple physiological processes, especially through the secretion of melatonin. Using mass-spectrometry-based proteomics and dedicated analysis tools, we identify proteins in the human pineal gland and analyze systematically their variation throughout the day and compare these changes in the pineal proteome between control specimens and donors diagnosed with autism. Results reveal diverse regulated clusters of proteins with, among others, catabolic carbohydrate process and cytoplasmic membrane-bounded vesicle-related proteins differing between day and night and/or control versus autism pineal glands. These data show novel and unexpected processes happening in the human pineal gland during the day/night rhythm as well as specific differences between autism donor pineal glands and those from controls.
Identifiants
pubmed: 33368564
doi: 10.1111/jpi.12713
pmc: PMC8047921
doi:
Substances chimiques
Proteins
0
Proteome
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12713Subventions
Organisme : Institute for Data Valorization (IVADO)
Organisme : Université Paris Diderot
Organisme : Cognacq-Jay foundation
Organisme : Centre National de la Recherche Scientifique
Organisme : Bettencourt-Schueller foundation
Organisme : Conny-Maeva foundation
Organisme : Institut National de la Santé et de la Recherche Médicale
Organisme : Agence Nationale de la Recherche
ID : Eranet-Neuron (ALTRUISM)
Organisme : Agence Nationale de la Recherche
ID : Labex BioPsy
Organisme : Agence Nationale de la Recherche
ID : Labex GenMed
Organisme : Fonds de Recherche du Québec - Santé
Organisme : Assistance Publique - Hôpitaux de Paris
Organisme : Orange foundation
Organisme : Institut Pasteur
Organisme : FondaMental foundation
Organisme : Fondation de France
Informations de copyright
© 2020 The Authors. Journal of Pineal Research published by John Wiley & Sons Ltd.
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