Effects of lipid composition on photothermal optical coherence tomography signals.
atherosclerosis
lipid
molecular contrast imaging
optical coherence tomography
photothermal optical coherence tomography
photothermal phenomena
Journal
Journal of biomedical optics
ISSN: 1560-2281
Titre abrégé: J Biomed Opt
Pays: United States
ID NLM: 9605853
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
31
08
2020
accepted:
01
12
2020
entrez:
28
12
2020
pubmed:
29
12
2020
medline:
28
9
2021
Statut:
ppublish
Résumé
Photothermal optical coherence tomography (PT-OCT) has the promise to offer structural images coregistered with chemical composition information, which can offer a significant impact in early detection of diseases such as atherosclerosis. We take the first step in understanding the relation between PT-OCT signals and the endogenous tissue composition by considering the interplay between the opto-thermo-physical properties of tissue as a function of its lipid composition and the ensuing effects on the PT-OCT signals. Multiparameter theoretical estimates for PT-OCT signal as a function of composition in a two-component lipid-water model are derived and discussed. Experimental data from various concentrations of lipid in the form of droplets and injections under bovine cardiac muscle align with theoretical predictions. Theoretical and experimental results suggest that the variations of heat capacity and mass density with tissue composition significantly contribute to the amount of optical path length difference measured by OCT phase. PT-OCT has the potential to offer key insights into the chemical composition of the subsurface lipid pools in tissue; however, the interpretation of results needs to be carried out by keeping the nonlinear interplay between the tissue of opto-thermo-physical properties and PT-OCT signals in mind.
Identifiants
pubmed: 33369310
pii: JBO-200283LR
doi: 10.1117/1.JBO.25.12.120501
pmc: PMC7757902
doi:
Substances chimiques
Lipids
0
Types de publication
Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIBIB NIH HHS
ID : P41 EB015903
Pays : United States
Références
Circ Cardiovasc Interv. 2016 Jul;9(7):
pubmed: 27406987
Opt Lett. 2018 Jun 1;43(11):2470-2473
pubmed: 29856406
Opt Express. 2008 Mar 31;16(7):4376-93
pubmed: 18542535
J Biomed Opt. 2012 Jun;17(6):061209
pubmed: 22734739
Biomed Opt Express. 2010 Jun 28;1(1):2-16
pubmed: 21258441
Transl Vis Sci Technol. 2018 Sep 4;7(5):4
pubmed: 30197836
Phys Med Biol. 1996 Aug;41(8):1381-99
pubmed: 8858726
Biomed Opt Express. 2018 Aug 02;9(9):3983-3997
pubmed: 30615710
JACC Cardiovasc Interv. 2013 Aug;6(8):838-46
pubmed: 23871513
Opt Lett. 2012 Sep 1;37(17):3678-80
pubmed: 22940988
Biomed Opt Express. 2013 Jul 05;4(8):1269-84
pubmed: 24009991
Biomed Opt Express. 2011 Feb 03;2(3):491-504
pubmed: 21412455
Am J Clin Nutr. 1993 Oct;58(4):477-83
pubmed: 8379502
J Am Coll Cardiol. 2012 Mar 20;59(12):1058-72
pubmed: 22421299
Opt Lett. 2010 Mar 1;35(5):700-2
pubmed: 20195324
Circ Cardiovasc Interv. 2012 Feb 1;5(1):55-61
pubmed: 22253357
Biomed Opt Express. 2017 Apr 26;8(5):2660-2686
pubmed: 28663897
Nano Lett. 2008 Oct;8(10):3461-7
pubmed: 18767886
Biomed Opt Express. 2016 Jun 16;7(7):2607-22
pubmed: 27446693
Circulation. 2002 Sep 24;106(13):1640-5
pubmed: 12270856
Sci Rep. 2019 Aug 27;9(1):12400
pubmed: 31455883
Photoacoustics. 2013 Dec 05;2(1):12-20
pubmed: 25302152
J Am Coll Cardiol. 2013 Mar 12;61(10):1041-51
pubmed: 23473409