The shift from pulmonary colonization to Pneumocystis pneumonia.
Aged
Carrier State
/ diagnosis
DNA, Fungal
Diagnostic Errors
/ prevention & control
Female
Genotype
Genotyping Techniques
Humans
Lung
/ microbiology
Male
Middle Aged
Pneumocystis carinii
/ classification
Pneumonia, Pneumocystis
/ diagnosis
Polymerase Chain Reaction
Retrospective Studies
Risk Factors
PcP
Pneumocystis jirovecii
genotypes
incubation
pulmonary colonization
Journal
Medical mycology
ISSN: 1460-2709
Titre abrégé: Med Mycol
Pays: England
ID NLM: 9815835
Informations de publication
Date de publication:
04 May 2021
04 May 2021
Historique:
received:
08
09
2020
revised:
24
11
2020
accepted:
04
12
2020
pubmed:
29
12
2020
medline:
6
10
2021
entrez:
28
12
2020
Statut:
ppublish
Résumé
Pulmonary specimen pairs from five patients who presented with pulmonary colonization and later developed Pneumocystis Pneumonia (PcP) were retrospectively examined for P. jirovecii genotyping. A match of genotypes in pulmonary specimen pairs of three patients was observed, whereas a partial match and a mismatch were observed in the fourth and fifth patients, respectively. The genotyping results suggest that the colonization state can differ from PcP but can also represent the incubation period of PcP. Clinicians should not systematically rule out the treatment of putative colonized patients and should at least discuss the initiation of prophylaxis on a case-by-case basis. The results suggest that clinicians should not systematically rule out the treatment of putative patients colonized by Pneumocystis jirovecii and should at least discuss prophylaxis initiation on a case-by-case basis.
Autres résumés
Type: plain-language-summary
(eng)
The results suggest that clinicians should not systematically rule out the treatment of putative patients colonized by Pneumocystis jirovecii and should at least discuss prophylaxis initiation on a case-by-case basis.
Identifiants
pubmed: 33369642
pii: 6053816
doi: 10.1093/mmy/myaa107
doi:
Substances chimiques
DNA, Fungal
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
510-513Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology.