[
Alpha-synuclein
PET imaging
Parkinson’s disease
Tracer development
Journal
European journal of nuclear medicine and molecular imaging
ISSN: 1619-7089
Titre abrégé: Eur J Nucl Med Mol Imaging
Pays: Germany
ID NLM: 101140988
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
09
07
2020
accepted:
20
10
2020
revised:
25
09
2020
pubmed:
29
12
2020
medline:
29
5
2021
entrez:
28
12
2020
Statut:
ppublish
Résumé
Deposition of misfolded alpha-synuclein (αSYN) aggregates in the human brain is one of the major hallmarks of synucleinopathies. However, a target-specific tracer to detect pathological aggregates of αSYN remains lacking. Here, we report the development of a positron emission tomography (PET) tracer based on anle138b, a compound shown to have therapeutic activity in animal models of neurodegenerative diseases. Specificity and selectivity of [ [ MODAG-001 provides a promising lead structure for future compound development as it combines a high affinity and good selectivity in fibril-binding assays with suitable pharmacokinetics and biodistribution properties.
Identifiants
pubmed: 33369690
doi: 10.1007/s00259-020-05133-x
pii: 10.1007/s00259-020-05133-x
pmc: PMC8113290
doi:
Substances chimiques
Carbon Radioisotopes
0
Radiopharmaceuticals
0
alpha-Synuclein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1759-1772Références
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