Paladin is a phosphoinositide phosphatase regulating endosomal VEGFR2 signalling and angiogenesis.

Animals Endothelial Cells / metabolism Mice Neovascularization, Physiologic Phosphatidylinositol 4,5-Diphosphate Phosphoinositide Phosphatases Phosphoprotein Phosphatases Signal Transduction Vascular Endothelial Growth Factor Receptor-2 / genetics
Paladin VEGFR2 endocytosis phosphatase phosphoinositide

Journal

EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049

Informations de publication

Date de publication:
03 02 2021
Historique:
received: 13 02 2020
revised: 07 11 2020
accepted: 18 11 2020
pubmed: 29 12 2020
medline: 1 6 2021
entrez: 28 12 2020
Statut: ppublish

Résumé

Cell signalling governs cellular behaviour and is therefore subject to tight spatiotemporal regulation. Signalling output is modulated by specialized cell membranes and vesicles which contain unique combinations of lipids and proteins. The phosphatidylinositol 4,5-bisphosphate (PI(4,5)P

Identifiants

DOI: 10.15252/embr.202050218 PMID: 33369848 PMC: PMC7857541
pubmed: 33369848
doi: 10.15252/embr.202050218
pmc: PMC7857541
doi:

Substances chimiques

Phosphatidylinositol 4,5-Diphosphate 0
Vascular Endothelial Growth Factor Receptor-2 EC 2.7.10.1
Pald1 protein, mouse EC 3.1.3.16
Phosphoprotein Phosphatases EC 3.1.3.16
Phosphoinositide Phosphatases EC 3.1.3.36

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e50218

Informations de copyright

© 2020 The Authors. Published under the terms of the CC BY 4.0 license.

Références

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Auteurs

Anja Nitzsche (A)

Science for Life Laboratory, The Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
ORCID: 0000-0003-0567-6790

Riikka Pietilä (R)

Science for Life Laboratory, The Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

Dominic T Love (DT)

Science for Life Laboratory, The Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

Chiara Testini (C)

Science for Life Laboratory, The Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

Takeshi Ninchoji (T)

Science for Life Laboratory, The Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

Ross O Smith (RO)

Science for Life Laboratory, The Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

Elisabet Ekvärn (E)

Science for Life Laboratory, The Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

Jimmy Larsson (J)

Science for Life Laboratory, The Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

Francis P Roche (FP)

Science for Life Laboratory, The Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

Isabel Egaña (I)

Science for Life Laboratory, The Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

Suvi Jauhiainen (S)

Science for Life Laboratory, The Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

Philipp Berger (P)

Laboratory of Nanoscale Biology, Paul-Scherrer Institute, Villigen, Switzerland.

Lena Claesson-Welsh (L)

Science for Life Laboratory, The Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
ORCID: 0000-0003-4275-2000

Mats Hellström (M)

Science for Life Laboratory, The Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
ORCID: 0000-0002-7088-9533

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Paladin is a phosphoinositide phosphatase...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Paladin is a phosphoinositide phosphatase...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Paladin is a phosphoinositide phosphatase...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Néovascularisation physiologique › Paladin is a phosphoinositide phosphatase...
questionsmedicales.fr › Lipides › Lipides membranaires › Phospholipides › Glycérophosphate › Acides phosphatidiques › Glycérophospholipides › Phosphatidyl inositols › Phosphates phosphatidylinositol › Phosphatidylinositol diphosphate-4,5 › Paladin is a phosphoinositide phosphatase...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Phosphoric monoester hydrolases › Phosphoinositide phosphatases › Paladin is a phosphoinositide phosphatase...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphoprotein Phosphatases › Paladin is a phosphoinositide phosphatase...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Paladin is a phosphoinositide phosphatase...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs aux facteurs de croissance endothéliale vasculaire › Récepteur-2 au facteur croissance endothéliale vasculaire › Paladin is a phosphoinositide phosphatase...