Efficacy of Long-term Use of 0.3% Sodium Hyaluronate Eye Drops for Traumatic Corneal Abrasion: A Randomized Controlled, Pilot Trial.
Administration, Ophthalmic
Adult
Corneal Injuries
/ drug therapy
Female
Follow-Up Studies
Hemidesmosomes
/ metabolism
Humans
Hyaluronic Acid
/ administration & dosage
Male
Middle Aged
Ophthalmic Solutions
/ administration & dosage
Pilot Projects
Prospective Studies
Treatment Outcome
Viscosupplements
/ administration & dosage
Wound Healing
/ drug effects
Journal
Cornea
ISSN: 1536-4798
Titre abrégé: Cornea
Pays: United States
ID NLM: 8216186
Informations de publication
Date de publication:
01 Oct 2021
01 Oct 2021
Historique:
received:
28
07
2020
accepted:
15
10
2020
pubmed:
29
12
2020
medline:
18
12
2021
entrez:
28
12
2020
Statut:
ppublish
Résumé
Traumatic corneal abrasion (TCA) causes damage to both corneal epithelium and the underlying hemidesmosomal junctions. Delayed recovery of hemidesmosomal junctions causes symptomatic episodes. However, there is no recommended treatment for recovery of hemidesmosomal junctions, indicating that a blank period exists in TCA treatment. In this study, the efficacy of long-term use of sodium hyaluronate on recovery of hemidesmosomal junctions during the blank period in TCA healing was investigated. In this prospective, randomized control pilot study, 60 patients with TCA were enrolled. The patients were randomized 1:1 to receive 0.3% sodium hyaluronate eye drops for 3 months (HA group) or observation alone (control group) after complete corneal epithelium recovery. The primary and secondary outcomes were the cumulative incidence of major and minor symptomatic episodes during a 12-month follow-up, respectively. Fifty-six subjects (29 in the HA group and 27 in the control group) completed the 12-month follow-up. The 12-month cumulative incidence rate of major symptomatic episodes was 20.7% in the HA group and 18.5% in the control group. No significant difference was found between the 2 groups (P = 0.838). The 12-month cumulative incidence rate of minor symptomatic episodes was 48.3% and 37.0% in the HA and control groups, respectively, with no significant difference (P = 0.397). Approximately one-fifth of patients with TCA experience major symptomatic episodes again within their 1-year follow-up. Long-term use of sodium hyaluronate in the period of recovery of hemidesmosomal junctions has no benefit to it.
Identifiants
pubmed: 33369934
doi: 10.1097/ICO.0000000000002625
pii: 00003226-202110000-00004
doi:
Substances chimiques
Ophthalmic Solutions
0
Viscosupplements
0
Hyaluronic Acid
9004-61-9
Banques de données
ClinicalTrials.gov
['NCT03000556']
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
1248-1252Informations de copyright
Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
The authors have no funding or conflicts of interest to disclose.
Références
Lin YB, Gardiner MF. Fingernail-induced corneal abrasions: case series from an ophthalmology emergency department. Cornea. 2014;33:691–695.
Goyal R, Shankar J, Fone DL, et al. Randomised controlled trial of ketorolac in the management of corneal abrasions. Acta Ophthalmol Scand. 2001;79:177–179.
Saccomano SJ, Ferrara LR. Managing corneal abrasions in primary care. Nurse Pract. 2014;39:1–6.
Miller DD, Hasan SA, Simmons N, et al. Recurrent corneal erosion: a comprehensive review. Clin Ophthalmol. 2019;13:325–335.
Krawczyk WS, Wilgram GF. Hemidesmosome and desmosome morphogenesis during epidermal wound healing. J Ultrastruct Res. 1973;45:93–101.
Arffa RC. Grayson's Diseases of the Cornea. 4th ed. St Louis: Mosby; 1997.
Okada Y, Saika S, Shirai K, et al. Disappearance of desmosomal components in rat corneal epithelium during wound healing. Ophthalmologica. 2001;215:61–65.
Weisenthal RW. External Disease and Cornea. Basic and Clinical Science Course: American Academy of Ophthalmology; 2017-2018. San Francisco, CA: American Academy of Ophthalmology; 2017.
Hykin PG, Foss AE, Pavesio C, et al. The natural history and management of recurrent corneal erosion: a prospective randomised trial. Eye (Lond). 1994;8:35–40.
Ahad MA, Anandan M, Tah V, et al. Randomized controlled study of ocular lubrication versus bandage contact lens in the primary treatment of recurrent corneal erosion syndrome. Cornea. 2013;32:1311–1314.
Jackson H. Effect of eye-pads on healing of simple corneal abrasions. Br Med J. 1960;2:713.
Lin T, Gong L. Sodium hyaluronate eye drops treatment for superficial corneal abrasion caused by mechanical damage: a randomized clinical trial in the People's Republic of China. Drug Des Devel Ther. 2015;9:687–694.
Thakrar R, Hemmati H. Treatment of recurrent corneal erosions. Available at: https://www.aao.org/eyenet/article/treatment-of-recurrent-corneal-erosions . Accessed March 2013.
Nishida T, Nakamura M, Mishima H, et al. Hyaluronan stimulates corneal epithelial migration. Exp Eye Res. 1991;53:753–758.
Saettone MF, Monti D, Torracca MT, et al. Mucoadhesive ophthalmic vehicles: evaluation of polymeric low-viscosity formulations. J Ocul Pharmacol. 1994;10:83–92.
Ziakas NG, Boboridis KG, Terzidou C, et al. Long-term follow up of autologous serum treatment for recurrent corneal erosions. Clin Exp Ophthalmol. 2010;38:683–687.
Dursun D, Kim MC, Solomon A, et al. Treatment of recalcitrant recurrent corneal erosions with inhibitors of matrix metalloproteinase-9, doxycycline and corticosteroids. Am J Ophthalmol. 2001;132:8–13.
Eke T, Morrison DA, Austin DJ. Recurrent symptoms following traumatic corneal abrasion: prevalence, severity, and the effect of a simple regimen of prophylaxis. Eye (Lond). 1999;13:345–347.