Understanding Traumatic Brain Injury in Females: A State-of-the-Art Summary and Future Directions.
Journal
The Journal of head trauma rehabilitation
ISSN: 1550-509X
Titre abrégé: J Head Trauma Rehabil
Pays: United States
ID NLM: 8702552
Informations de publication
Date de publication:
01 01 2021
01 01 2021
Historique:
entrez:
28
12
2020
pubmed:
29
12
2020
medline:
16
10
2021
Statut:
ppublish
Résumé
In this report, we identify existing issues and challenges related to research on traumatic brain injury (TBI) in females and provide future directions for research. In 2017, the National Institutes of Health, in partnership with the Center for Neuroscience and Regenerative Medicine and the Defense and Veterans Brain Injury Center, hosted a workshop that focused on the unique challenges facing researchers, clinicians, patients, and other stakeholders regarding TBI in women. The goal of this "Understanding TBI in Women" workshop was to bring together researchers and clinicians to identify knowledge gaps, best practices, and target populations in research on females and/or sex differences within the field of TBI. The workshop, and the current literature, clearly highlighted that females have been underrepresented in TBI studies and clinical trials and have often been excluded (or ovariectomized) in preclinical studies. Such an absence in research on females has led to an incomplete, and perhaps inaccurate, understanding of TBI in females. The presentations and discussions centered on the existing knowledge regarding sex differences in TBI research and how these differences could be incorporated in preclinical and clinical efforts going forward. Now, a little over 2 years later, we summarize the issues and state of the science that emerged from the "Understanding TBI in Women" workshop while incorporating updates where they exist. Overall, despite some progress, there remains an abundance of research focused on males and relatively little explicitly on females.
Identifiants
pubmed: 33369993
doi: 10.1097/HTR.0000000000000652
pii: 00001199-202101000-00009
pmc: PMC9070050
mid: NIHMS1799425
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
E1-E17Subventions
Organisme : Intramural CDC HHS
ID : CC999999
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD071089
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS112694
Pays : United States
Informations de copyright
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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