Localization of Carbon-Carbon Double Bond and Cyclopropane Sites in Cardiolipins via Gas-Phase Charge Inversion Reactions.
Journal
Journal of the American Society for Mass Spectrometry
ISSN: 1879-1123
Titre abrégé: J Am Soc Mass Spectrom
Pays: United States
ID NLM: 9010412
Informations de publication
Date de publication:
03 Feb 2021
03 Feb 2021
Historique:
pubmed:
29
12
2020
medline:
29
12
2020
entrez:
28
12
2020
Statut:
ppublish
Résumé
Cardiolipins (CLs) are comprised of two phosphatic acid moieties bound to a central glycerol backbone and are substituted with four acyl chains. Consequently, a vast number of distinct CL structures are possible in different biological contexts, representing a significant analytical challenge. Electrospray ionization tandem mass spectrometry (ESI-MS/MS) has become a widely used approach for the detection, characterization, and quantitation of complex lipids, including CLs. Central to this approach is fragmentation of the [CLs - H]
Identifiants
pubmed: 33370110
doi: 10.1021/jasms.0c00348
pmc: PMC8557092
mid: NIHMS1751049
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
455-464Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM118484
Pays : United States
Organisme : NIGMS NIH HHS
ID : R37 GM045372
Pays : United States
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