Occupational exposures and exacerbations of asthma and COPD-A general population study.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
21
10
2020
accepted:
27
11
2020
entrez:
28
12
2020
pubmed:
29
12
2020
medline:
4
2
2021
Statut:
epublish
Résumé
Recent studies suggest that occupational inhalant exposures trigger exacerbations of asthma and chronic obstructive pulmonary disease, but findings are conflicting. We included 7,768 individuals with self-reported asthma (n = 3,215) and/or spirometric airflow limitation (forced expiratory volume in 1 second (FEV1)/ forced expiratory volume (FVC) <0.70) (n = 5,275) who participated in The Copenhagen City Heart Study or The Copenhagen General Population Study from 2001-2016. Occupational exposure was assigned by linking job codes with job exposure matrices, and exacerbations were defined by register data on oral corticosteroid treatment, emergency care unit assessment or hospital admission. Associations between occupational inhalant exposure each year of follow-up and exacerbation were assessed by Cox regression with time varying exposure and age as the underlying time scale. Participants were followed for a median of 4.6 years (interquartile range, IQR 5.4), during which 870 exacerbations occurred. Exacerbations were not associated with any of the selected exposures (high molecular weight sensitizers, low molecular weight sensitizers, irritants or low and high levels of mineral dust, biological dust, gases & fumes or the composite variable vapours, gases, dusts or fumes). Hazards ratios ranged from 0.8 (95% confidence interval: 0.7;1.0) to 1.2 (95% confidence interval: 0.9;1.7). Exacerbations of obstructive airway disease were not associated with occupational inhalant exposures assigned by a job exposure matrix. Further studies with alternative exposure assessment are warranted.
Identifiants
pubmed: 33370308
doi: 10.1371/journal.pone.0243826
pii: PONE-D-20-33101
pmc: PMC7769267
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0243826Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Thorax. 2006 Mar;61(3):250-8
pubmed: 16517585
Respir Med. 2015 Dec;109(12):1562-8
pubmed: 26560643
Respir Med. 2019 Feb;147:76-78
pubmed: 30704704
Int J Chron Obstruct Pulmon Dis. 2017 Jan 11;12:233-242
pubmed: 28138233
Ann Am Thorac Soc. 2018 Aug;15(8):947-954
pubmed: 29979621
Occup Environ Med. 2018 Jul;75(7):507-514
pubmed: 29650699
Thorax. 2005 Nov;60(11):925-31
pubmed: 16055622
Respir Med. 2019 Aug;155:141-147
pubmed: 31362177
Am J Respir Crit Care Med. 2011 Apr 1;183(7):891-7
pubmed: 20935112
Thorax. 2018 Apr;73(4):313-320
pubmed: 29074814
Occup Med (Lond). 2016 Jul;66(5):358-64
pubmed: 27067914
Eur Respir J. 2007 Sep;30(3):452-6
pubmed: 17537763
Lancet. 2007 Sep 1;370(9589):786-96
pubmed: 17765528
Chest. 2011 Apr;139(4):752-763
pubmed: 20884729
Pulm Pharmacol Ther. 2008 Aug;21(4):682-8
pubmed: 18541448
Eur Respir J. 2010 Oct;36(4):743-50
pubmed: 20351033
J Allergy Clin Immunol Pract. 2017 Jul - Aug;5(4):918-927
pubmed: 28689842
Scand J Public Health. 2012 Jun;40(4):377-84
pubmed: 22786923
Allergy. 2018 Feb;73(2):284-294
pubmed: 28722758
Occup Environ Med. 2019 Feb;76(2):105-113
pubmed: 30598459
JAMA Intern Med. 2014 Jan;174(1):15-22
pubmed: 24217719
N Engl J Med. 2015 Sep 24;373(13):1241-9
pubmed: 26398072
BMC Pulm Med. 2017 Apr 27;17(1):74
pubmed: 28449686
Respirology. 2016 Oct;21(7):1152-65
pubmed: 27028990
J Glob Health. 2015 Dec;5(2):020415
pubmed: 26755942
Int J Chron Obstruct Pulmon Dis. 2016 Dec 12;11:3079-3091
pubmed: 28003742
BMC Pulm Med. 2016 Nov 15;16(1):148
pubmed: 27842581
Occup Environ Med. 1998 Oct;55(10):651-6
pubmed: 9930084
Chemosphere. 2019 Dec;237:124497
pubmed: 31400740
Int J Epidemiol. 2001 Feb;30(1):145-51
pubmed: 11171876
J Allergy Clin Immunol Pract. 2013 Nov-Dec;1(6):618-22
pubmed: 24565709
Respir Med. 2018 Sep;142:29-35
pubmed: 30170798
Respir Med. 2007 Mar;101(3):481-9
pubmed: 16914299
Expert Opin Pharmacother. 2009 Mar;10(4):719-22
pubmed: 19284368
Eur Respir J. 2004 Dec;24(6):942-6
pubmed: 15572536
Lancet Respir Med. 2016 Jun;4(6):454-62
pubmed: 27061878
Eur Respir J. 2006 Apr;27(4):720-5
pubmed: 16585079
Lancet Respir Med. 2017 Sep;5(9):691-706
pubmed: 28822787
Int J Epidemiol. 2019 Oct 1;48(5):1413-1413k
pubmed: 31730707
Ann Occup Hyg. 2007 Nov;51(8):665-78
pubmed: 17932083
Thorax. 2018 Nov;73(11):1008-1015
pubmed: 29574416
Scand J Public Health. 2011 Jul;39(7 Suppl):30-3
pubmed: 21775347
J Asthma. 2007 May;44(4):341-5
pubmed: 17530535
J Asthma. 2011 Jun;48(5):470-81
pubmed: 21486196
Am J Respir Crit Care Med. 2015 Mar 1;191(5):557-65
pubmed: 25562375
J Allergy Clin Immunol. 2012 Mar;129(3 Suppl):S34-48
pubmed: 22386508
Scand J Public Health. 2011 Jul;39(7 Suppl):38-41
pubmed: 21775349
BMJ Open Respir Res. 2019 Mar 30;6(1):e000407
pubmed: 31179005
Am J Respir Crit Care Med. 2003 Mar 1;167(5):787-97
pubmed: 12598220
Eur Respir J. 2003 Nov;22(5):802-8
pubmed: 14621088