Serum amyloid A level correlates with T2 lesion volume and cortical volume in patients with multiple sclerosis.
Cortical atrophy
Inflammation
Multiple sclerosis
Serum amyloid a
T2 lesion volume
Journal
Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498
Informations de publication
Date de publication:
15 02 2021
15 02 2021
Historique:
received:
04
10
2020
revised:
10
12
2020
accepted:
16
12
2020
pubmed:
29
12
2020
medline:
26
5
2021
entrez:
28
12
2020
Statut:
ppublish
Résumé
It is unclear whether brain atrophy in multiple sclerosis (MS) is associated with not only neuroinflammation but also systemic inflammation. Here we found that systemic inflammatory marker serum amyloid A (SAA) was moderately correlated with cortical volume in the patients with clinically isolated syndrome (CIS) and MS (r = -0.41, p = 0.019). SAA was also significantly correlated with T2 lesion volume (T2LV) even after adjusting for age, disease duration, and disease modifying therapy (p = 0.0050). Thus, systemic inflammation may be associated with cortical atrophy, possibly via an increase in the T2LV in patients with CIS/MS.
Identifiants
pubmed: 33370672
pii: S0165-5728(20)30727-X
doi: 10.1016/j.jneuroim.2020.577466
pii:
doi:
Substances chimiques
Serum Amyloid A Protein
0
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
577466Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.