Animal and Human Vaccines against West Nile Virus.
West Nile virus
animal vaccines
flavivirus
human vaccines
Journal
Pathogens (Basel, Switzerland)
ISSN: 2076-0817
Titre abrégé: Pathogens
Pays: Switzerland
ID NLM: 101596317
Informations de publication
Date de publication:
21 Dec 2020
21 Dec 2020
Historique:
received:
18
11
2020
revised:
17
12
2020
accepted:
17
12
2020
entrez:
29
12
2020
pubmed:
30
12
2020
medline:
30
12
2020
Statut:
epublish
Résumé
West Nile virus (WNV) is a widely distributed enveloped flavivirus transmitted by mosquitoes, which main hosts are birds. The virus sporadically infects equids and humans with serious economic and health consequences, as infected individuals can develop a severe neuroinvasive disease that can even lead to death. Nowadays, no WNV-specific therapy is available and vaccines are only licensed for use in horses but not for humans. While several methodologies for WNV vaccine development have been successfully applied and have contributed to significantly reducing its incidence in horses in the US, none have progressed to phase III clinical trials in humans. This review addresses the status of WNV vaccines for horses, birds, and humans, summarizing and discussing the challenges they face for their clinical advance and their introduction to the market.
Identifiants
pubmed: 33371384
pii: pathogens9121073
doi: 10.3390/pathogens9121073
pmc: PMC7767344
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria
ID : RTA2015-00009-00-00 and E-RTA2017-00003-C02-01
Organisme : Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria
ID : E-RTA2017-00003-C02-01
Organisme : Comunidad de Madrid
ID : S2018/BAA-4370-ZOOVIR (PLATESA2-CM)
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