The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related Diseases.
SASP
age-related disease
cancer therapy
inflammation
senescence
senolytic
senomorphic
Journal
Biology
ISSN: 2079-7737
Titre abrégé: Biology (Basel)
Pays: Switzerland
ID NLM: 101587988
Informations de publication
Date de publication:
21 Dec 2020
21 Dec 2020
Historique:
received:
30
11
2020
revised:
18
12
2020
accepted:
19
12
2020
entrez:
29
12
2020
pubmed:
30
12
2020
medline:
30
12
2020
Statut:
epublish
Résumé
Cellular senescence represents a robust tumor-protecting mechanism that halts the proliferation of stressed or premalignant cells. However, this state of stable proliferative arrest is accompanied by the Senescence-Associated Secretory Phenotype (SASP), which entails the copious secretion of proinflammatory signals in the tissue microenvironment and contributes to age-related conditions, including, paradoxically, cancer. Novel therapeutic strategies aim at eliminating senescent cells with the use of senolytics or abolishing the SASP without killing the senescent cell with the use of the so-called "senomorphics". In addition, recent works demonstrate the possibility of modifying the composition of the secretome by genetic or pharmacological intervention. The purpose is not to renounce the potent immunostimulatory nature of SASP, but rather learning to modulate it for combating cancer and other age-related diseases. This review describes the main molecular mechanisms regulating the SASP and reports the evidence of the feasibility of abrogating or modulating the SASP, discussing the possible implications of both strategies.
Identifiants
pubmed: 33371508
pii: biology9120485
doi: 10.3390/biology9120485
pmc: PMC7767554
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : AIRC 5x1000
ID : 21147
Organisme : Progetto di Ricerca 2019 - Sapienza University of Rome
ID : RP11916B79E083FC.
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