Outdoor air pollution from industrial chemicals causing new onset of asthma or COPD: a systematic review protocol.

Air pollution Chronic obstructive pulmonary disease Inhaled particles Occupational exposure Outdoor exposure Respiratory disease Systematic literature review

Journal

Journal of occupational medicine and toxicology (London, England)
ISSN: 1745-6673
Titre abrégé: J Occup Med Toxicol
Pays: England
ID NLM: 101245790

Informations de publication

Date de publication:
28 Dec 2020
Historique:
received: 02 04 2020
accepted: 08 12 2020
entrez: 29 12 2020
pubmed: 30 12 2020
medline: 30 12 2020
Statut: epublish

Résumé

Until today, industrial sources contribute to the multifaceted contamination of environmental air. Exposure to air pollutants has the potential to initiate and promote asthma and chronic obstructive pulmonary disease (COPD). At global scale, both entities cause the majority of about 4 million annual deaths by respiratory disease. However, we identified industrial contamination as a subgroup of air pollution that may be associated with this burden and is underinvestigated in research. Therefore, the aim of this study is to investigate associations between substances industrially released into environmental air and the occurrence of asthma and COPD in the human population. Here we present the protocol for our systematic review of the current evidence. The following determinations will be applied during the systematic review process and are specified in the protocol that complies with the PRISMA-P statement. Populations of children and adults, as well as outdoor workers, exposed to industrially released air pollutants are of interest. Eligible studies may include subjects as controls who are non- or less exposed to the investigated air pollutants. The outcomes new-onset asthma and/or COPD investigated with risk ratio, odds ratio, hazard ratio, incidence rate ratio, cumulative incidence, and incidence rate are eligible. We will search the electronic literature databases EMBASE, MEDLINE, and Web of Science for peer-reviewed reports of incidence studies and incidence case-control studies. After systematic sorting of initial records, included studies will be subjected to quality assessment. Data will be synthesized qualitatively and, if appropriate, quantitatively for risk ratio and odds ratio. We will maintain and provide a PRISMA report. Results of this systematic review may indicate alterations of incidence and risk of asthma and/or COPD in populations within industrial exposure radiuses including outdoor workplaces. Specific causal substances and compositions will be identified, but results will depend on the exposure assessment of the eligible studies. Our approach covers effects of industrial contributions to overall air pollution if studies reportedly attribute investigated emissions to industry. Results of this study may raise the question wether the available higher-level evidence sufficiently covers the current scale of industrial exposure scenarios and their potential harm to respiratory health. This protocol was registered in PROSPERO, registration number CRD42020151573 .

Sections du résumé

BACKGROUND BACKGROUND
Until today, industrial sources contribute to the multifaceted contamination of environmental air. Exposure to air pollutants has the potential to initiate and promote asthma and chronic obstructive pulmonary disease (COPD). At global scale, both entities cause the majority of about 4 million annual deaths by respiratory disease. However, we identified industrial contamination as a subgroup of air pollution that may be associated with this burden and is underinvestigated in research. Therefore, the aim of this study is to investigate associations between substances industrially released into environmental air and the occurrence of asthma and COPD in the human population. Here we present the protocol for our systematic review of the current evidence.
METHODS METHODS
The following determinations will be applied during the systematic review process and are specified in the protocol that complies with the PRISMA-P statement. Populations of children and adults, as well as outdoor workers, exposed to industrially released air pollutants are of interest. Eligible studies may include subjects as controls who are non- or less exposed to the investigated air pollutants. The outcomes new-onset asthma and/or COPD investigated with risk ratio, odds ratio, hazard ratio, incidence rate ratio, cumulative incidence, and incidence rate are eligible. We will search the electronic literature databases EMBASE, MEDLINE, and Web of Science for peer-reviewed reports of incidence studies and incidence case-control studies. After systematic sorting of initial records, included studies will be subjected to quality assessment. Data will be synthesized qualitatively and, if appropriate, quantitatively for risk ratio and odds ratio. We will maintain and provide a PRISMA report.
DISCUSSION CONCLUSIONS
Results of this systematic review may indicate alterations of incidence and risk of asthma and/or COPD in populations within industrial exposure radiuses including outdoor workplaces. Specific causal substances and compositions will be identified, but results will depend on the exposure assessment of the eligible studies. Our approach covers effects of industrial contributions to overall air pollution if studies reportedly attribute investigated emissions to industry. Results of this study may raise the question wether the available higher-level evidence sufficiently covers the current scale of industrial exposure scenarios and their potential harm to respiratory health.
TRIAL REGISTRATION BACKGROUND
This protocol was registered in PROSPERO, registration number CRD42020151573 .

Identifiants

pubmed: 33371904
doi: 10.1186/s12995-020-00289-6
pii: 10.1186/s12995-020-00289-6
pmc: PMC7768640
doi:

Types de publication

Journal Article

Langues

eng

Pagination

38

Subventions

Organisme : EU-COST action DiMoPEx, EU Framework Program Horizon 2020
ID : CA-15129
Organisme : Estonian Ministry of Education and Research
ID : IUT34-17
Organisme : Swedish Research Council for Health, Working Life and Welfare (FORTE)
ID : 2017-00690

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Auteurs

Harald Lux (H)

Occupational, Social and Environmental Medicine, University Hospital Jena - Friedrich Schiller University Jena, Erlanger Allee 103, 07747, Jena, Germany. harald.lux@med.uni-jena.de.
Department of Psychiatry and Psychotherapy, Ruppiner Kliniken, Neuruppin, Germany. harald.lux@med.uni-jena.de.

Xaver Baur (X)

European Society for Environmental and Occupational Medicine, Berlin, Germany.
Emeritus University of Hamburg, Hamburg, Germany.

Lygia Therese Budnik (LT)

Translational Toxicology and Immunology Unit, Institute for Occupational and Maritime Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Astrid Heutelbeck (A)

Occupational, Social and Environmental Medicine, University Hospital Jena - Friedrich Schiller University Jena, Erlanger Allee 103, 07747, Jena, Germany.

João Paulo Teixeira (JP)

Environmental Health Department, National Institute of Health, Porto, Portugal.
EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.

Emeri Neumann (E)

Institute of Family Medicine and Public Health, University of Tartu, Tartu, Estonia.

Diana Adliene (D)

Department of Physics, Kaunas University of Technology, Kaunas, Lithuania.

Judita Puišo (J)

Department of Physics, Kaunas University of Technology, Kaunas, Lithuania.

David Lucas (D)

EA4324 ORPHY Laboratory, Occidental Brittany University Brest, Brest, France.

Jakob Löndahl (J)

Ergonomics and Aerosol Technology, Lund University, Lund, Sweden.

Athanasios Damialis (A)

Chair and Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Centre Munich, Augsburg, Germany.

Ozlem Goksel (O)

Laboratory of Occupational & Environmental Respiratory Diseases, Division of Immunology, Allergy and Asthma, Department of Pulmonary Medicine, Faculty of Medicine, EGE University, Izmir, Turkey.

Hans Orru (H)

Institute of Family Medicine and Public Health, University of Tartu, Tartu, Estonia.
Section of Sustainable Health, Umea University, Umea, Sweden.

Classifications MeSH