Two populations of self-maintaining monocyte-independent macrophages exist in adult epididymis and testis.
epididymis
macrophgaes
monocytes
ontogeny
testis
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
05 01 2021
05 01 2021
Historique:
entrez:
29
12
2020
pubmed:
30
12
2020
medline:
15
5
2021
Statut:
ppublish
Résumé
Macrophages are the principal immune cells of the epididymis and testis, but their origins, heterogeneity, development, and maintenance are not well understood. Here, we describe distinct populations of epididymal and testicular macrophages that display an organ-specific cellular identity. Combining in vivo fate-mapping, chimeric and parabiotic mouse models with in-depth cellular analyses, we found that CD64
Identifiants
pubmed: 33372158
pii: 2013686117
doi: 10.1073/pnas.2013686117
pmc: PMC7817195
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no competing interest.
Références
J Exp Med. 2009 Dec 21;206(13):3089-100
pubmed: 19995948
J Invest Dermatol. 2004 Mar;122(3):670-2
pubmed: 15086552
J Immunol. 2015 Jun 1;194(11):5455-64
pubmed: 25917085
Cell Stem Cell. 2011 Jul 8;9(1):64-73
pubmed: 21726834
Science. 2019 Mar 15;363(6432):
pubmed: 30872492
Nat Immunol. 2016 Feb;17(2):159-68
pubmed: 26642357
Immunity. 2016 Mar 15;44(3):439-449
pubmed: 26982352
PLoS One. 2011;6(12):e28452
pubmed: 22164293
Nat Commun. 2013;4:1886
pubmed: 23695680
Immunity. 2013 Apr 18;38(4):792-804
pubmed: 23601688
Nat Immunol. 2014 Oct;15(10):929-937
pubmed: 25151491
J Immunol. 2002 May 15;168(10):4827-31
pubmed: 11994430
Infect Immun. 2014 Mar;82(3):1104-11
pubmed: 24366252
Eur Urol. 2015 Sep;68(3):428-35
pubmed: 25542628
J Exp Med. 2017 Oct 2;214(10):2829-2841
pubmed: 28784628
Sci Rep. 2017 Feb 13;7:42391
pubmed: 28205525
Nat Commun. 2016 Jan 27;7:10321
pubmed: 26813785
Immunity. 2016 Apr 19;44(4):755-68
pubmed: 26992565
Biol Reprod. 1985 Oct;33(3):588-95
pubmed: 4052526
Am J Physiol Cell Physiol. 2020 Dec 1;319(6):C997-C1010
pubmed: 32991210
Cell Immunol. 2018 Aug;330:5-15
pubmed: 29475558
J Immunol Methods. 2018 Jun;457:66-72
pubmed: 29630967
J Exp Med. 2018 Jun 4;215(6):1507-1518
pubmed: 29789388
Mol Hum Reprod. 2020 Jan 1;26(1):14-29
pubmed: 31778536
Science. 2012 Apr 6;336(6077):86-90
pubmed: 22442384
Immunity. 2012 Dec 14;37(6):1050-1060
pubmed: 23177320
Blood Cells Mol Dis. 2013 Dec;51(4):220-5
pubmed: 24095199
Curr Opin Immunol. 2006 Feb;18(1):39-48
pubmed: 16337366
J Exp Med. 2011 Aug 29;208(9):1901-16
pubmed: 21825019
J Crohns Colitis. 2019 Feb 1;13(2):245-258
pubmed: 30535144
Nat Immunol. 2012 Nov;13(11):1118-28
pubmed: 23023392
Cell. 2008 Feb 22;132(4):631-44
pubmed: 18295580
Science. 2011 Jun 10;332(6035):1284-8
pubmed: 21566158
Mol Hum Reprod. 2020 Apr 24;26(4):215-227
pubmed: 32011693
Cell. 2019 Sep 5;178(6):1509-1525.e19
pubmed: 31491389
J Reprod Immunol. 2018 Apr;126:11-17
pubmed: 29421624
Genesis. 2007 Sep;45(9):593-605
pubmed: 17868096
Science. 1995 Sep 8;269(5229):1427-9
pubmed: 7660125
Development. 1999 Nov;126(22):5073-84
pubmed: 10529424
Nat Commun. 2020 Sep 1;11(1):4375
pubmed: 32873797
Biol Reprod. 2019 Mar 1;100(3):849-861
pubmed: 30398566
Nat Commun. 2016 Jun 13;7:ncomms11852
pubmed: 27292029
Biol Reprod. 2003 Jan;68(1):95-104
pubmed: 12493700
Oncogene. 2000 Jul 13;19(30):3335-42
pubmed: 10918590
Nat Rev Immunol. 2015 Dec;15(12):731-44
pubmed: 26603899
Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14853-8
pubmed: 15466706
Nature. 2011 Jun 08;475(7355):222-5
pubmed: 21654748
BMC Dev Biol. 2001;1:4
pubmed: 11299042
J Clin Invest. 1997 Nov 15;100(10):2552-61
pubmed: 9366570
Nat Immunol. 2012 Jun 24;13(8):753-60
pubmed: 22729249
Nature. 2015 Feb 26;518(7540):547-51
pubmed: 25470051
Cell. 1991 May 17;65(4):677-89
pubmed: 1709592
FEBS Lett. 1997 May 5;407(3):313-9
pubmed: 9175875
Nat Immunol. 2019 Jan;20(1):29-39
pubmed: 30538339
Immunity. 2015 Apr 21;42(4):665-78
pubmed: 25902481
Chem Immunol Allergy. 2005;88:1-14
pubmed: 16129933
Immunity. 2013 Nov 14;39(5):925-38
pubmed: 24184057
Nat Immunol. 2016 Jan;17(1):2-8
pubmed: 26681456
J Exp Med. 2008 May 12;205(5):1187-99
pubmed: 18458114
J Immunol. 2017 Jun 1;198(11):4327-4340
pubmed: 28461571
Stem Cells Dev. 2014 Jun 1;23(11):1168-77
pubmed: 24417306
J Exp Med. 2015 Sep 21;212(10):1497-512
pubmed: 26347472