Comparative Study between Nd-YAG laser, fractional CO2 Laser, and combined Nd-YAG with fractional CO2 Laser in the Management of keloid: clinical and molecular Study.
Fractional CO2 laser
Keloid
Nd-YAG laser
procollagen I
Journal
Journal of cosmetic dermatology
ISSN: 1473-2165
Titre abrégé: J Cosmet Dermatol
Pays: England
ID NLM: 101130964
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
revised:
04
10
2020
received:
29
07
2020
accepted:
23
10
2020
pubmed:
30
12
2020
medline:
15
5
2021
entrez:
29
12
2020
Statut:
ppublish
Résumé
Fractional CO2 laser and Nd-YAG laser have been reported to have promising results in the management of keloids. So far, there have been no comparative studies between these laser modalities. The study aimed to compare the efficacy of fractional CO2, Nd-YAG, and a combination of both in the management of keloids. Forty-five keloid patients were divided into 3 equal groups: the first received fractional CO2 only, the second received Nd-YAG only, and the third received a combination of both lasers. Each group received its designated treatment every 4 weeks for 4 sessions. The improvement was evaluated by the "Patient and Observer Scar Assessment Scale" (POSAS). Detection of procollagen I mRNA by RT-PCR analysis was done. The assessment by POSAS showed the most significant clinical improvement in the combination group and a less significant improvement in the fractional CO2 group, while the least improvement was seen in the Nd-YAG group. Molecular assessment via procollagen I yielded matching results. The study showed that the combination of fractional CO2 and Nd-YAG lasers has a synergistic effect being the most effective in the management of keloids, fractional CO2 being more effective than ND-YAG and Nd-YAG being the least effective.
Sections du résumé
BACKGROUND
BACKGROUND
Fractional CO2 laser and Nd-YAG laser have been reported to have promising results in the management of keloids. So far, there have been no comparative studies between these laser modalities.
AIMS
OBJECTIVE
The study aimed to compare the efficacy of fractional CO2, Nd-YAG, and a combination of both in the management of keloids.
PATIENTS AND METHODS
METHODS
Forty-five keloid patients were divided into 3 equal groups: the first received fractional CO2 only, the second received Nd-YAG only, and the third received a combination of both lasers. Each group received its designated treatment every 4 weeks for 4 sessions. The improvement was evaluated by the "Patient and Observer Scar Assessment Scale" (POSAS). Detection of procollagen I mRNA by RT-PCR analysis was done.
RESULTS
RESULTS
The assessment by POSAS showed the most significant clinical improvement in the combination group and a less significant improvement in the fractional CO2 group, while the least improvement was seen in the Nd-YAG group. Molecular assessment via procollagen I yielded matching results.
CONCLUSION
CONCLUSIONS
The study showed that the combination of fractional CO2 and Nd-YAG lasers has a synergistic effect being the most effective in the management of keloids, fractional CO2 being more effective than ND-YAG and Nd-YAG being the least effective.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1124-1132Informations de copyright
© 2020 Wiley Periodicals LLC.
Références
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