Expression of GSK3β, PICK1, NEFL, C4, NKCC1 and Synaptophysin in peripheral blood mononuclear cells of the first-episode schizophrenia patients.

Carrier Proteins Complement C4 Female Glycogen Synthase Kinase 3 beta / genetics Humans Leukocytes, Mononuclear / metabolism Male Neurofilament Proteins Neuronal Plasticity Nuclear Proteins / metabolism Schizophrenia / genetics Solute Carrier Family 12, Member 2 Synaptophysin / genetics
First-episode schizophrenia GSK3β NEFL PICK1 mRNA

Journal

Asian journal of psychiatry
ISSN: 1876-2026
Titre abrégé: Asian J Psychiatr
Pays: Netherlands
ID NLM: 101517820

Informations de publication

Date de publication:
Jan 2021
Historique:
received: 14 05 2020
revised: 26 10 2020
accepted: 10 12 2020
pubmed: 30 12 2020
medline: 22 6 2021
entrez: 29 12 2020
Statut: ppublish

Résumé

Schizophrenia (SZ) is a severe neurodevelopmental disease with unknown pathogenic mechanisms characterized with impaired cognitive function. The disturbed synaptic plasticity and synaptic loss have been widely reported in SZ. In this study, 41 first-episode schizophrenia (FES) patients and 44 healthy controls (HC) were recruited and the expression of six genes commonly relevant to synaptic functions was examined in the peripheral blood mononuclear cells (PBMCs). These genes were glycogen synthase kinase 3β (GSK3β), protein interacting with C-kinase 1 (PICK1), synaptophysin (SYP), neurofilament light (NEFL), complement component 4 (C4) and Na

Identifiants

DOI: 10.1016/j.ajp.2020.102520 PMID: 33373836
pubmed: 33373836
pii: S1876-2018(20)30633-X
doi: 10.1016/j.ajp.2020.102520
pii:
doi:

Substances chimiques

Carrier Proteins 0
Complement C4 0
Neurofilament Proteins 0
Nuclear Proteins 0
PICk1 protein, human 0
SLC12A2 protein, human 0
Solute Carrier Family 12, Member 2 0
Synaptophysin 0
neurofilament protein L 0
Glycogen Synthase Kinase 3 beta EC 2.7.11.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

102520

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Auteurs

Tingting Zhang (T)

Department of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.

Yamei Tang (Y)

Department of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.

Xiudeng Yang (X)

Department of Laboratory Medicine, The First Affifiliated Hospital of Shaoyang University, Shaoyang, Hunan, 422001, China.

Xuyi Wang (X)

National Clinical Research Center for Mental Disorders, Department of Psychaitry, The Second Xiangya Hospital of Central South University, China National Technology Institute on Mental Disorders, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha 410011, Hunan, China.

Shan Ding (S)

National Clinical Research Center for Mental Disorders, Department of Psychaitry, The Second Xiangya Hospital of Central South University, China National Technology Institute on Mental Disorders, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha 410011, Hunan, China.

Kai Huang (K)

National Clinical Research Center for Mental Disorders, Department of Psychaitry, The Second Xiangya Hospital of Central South University, China National Technology Institute on Mental Disorders, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha 410011, Hunan, China.

Yong Liu (Y)

National Clinical Research Center for Mental Disorders, Department of Psychaitry, The Second Xiangya Hospital of Central South University, China National Technology Institute on Mental Disorders, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha 410011, Hunan, China. Electronic address: csuliuyongpp@csu.edu.cn.

Bing Lang (B)

National Clinical Research Center for Mental Disorders, Department of Psychaitry, The Second Xiangya Hospital of Central South University, China National Technology Institute on Mental Disorders, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha 410011, Hunan, China. Electronic address: bing.lang@csu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Expression of GSK3β, PICK1, NEFL, C4, NKCC1...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Immunoprotéines › Protéines du système du complément › Complément C4 › Expression of GSK3β, PICK1, NEFL, C4, NKCC1...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Proline-directed protein kinases › Glycogen Synthase Kinase 3 › Glycogen synthase kinase 3 beta › Expression of GSK3β, PICK1, NEFL, C4, NKCC1...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Expression of GSK3β, PICK1, NEFL, C4, NKCC1...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Expression of GSK3β, PICK1, NEFL, C4, NKCC1...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines neurofilamenteuses › Expression of GSK3β, PICK1, NEFL, C4, NKCC1...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Plasticité neuronale › Expression of GSK3β, PICK1, NEFL, C4, NKCC1...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Expression of GSK3β, PICK1, NEFL, C4, NKCC1...
questionsmedicales.fr › Troubles mentaux › Schizophrénie et troubles avec traits psychotiques › Schizophrénie › Expression of GSK3β, PICK1, NEFL, C4, NKCC1...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Symporteurs des ions sodium-potassium-chlorure › Membre-2 de la famille-12 des transporteurs de solutés › Expression of GSK3β, PICK1, NEFL, C4, NKCC1...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Synaptophysine › Expression of GSK3β, PICK1, NEFL, C4, NKCC1...