Basolateral Secretion from Caco-2 Cells Pretreated with Fecal Waters from Breast Cancer Patients Affects MCF7 Cell Viability.
Bacteria
/ classification
Breast Neoplasms
/ microbiology
Caco-2 Cells
Cell Survival
DNA, Bacterial
/ analysis
Enterocytes
/ metabolism
Fatty Acids, Volatile
/ analysis
Feces
/ microbiology
Female
Gastrointestinal Microbiome
/ physiology
Gene Expression
Humans
Lipid Metabolism
/ genetics
MCF-7 Cells
Middle Aged
breast cancer
gut
lipid metabolism
microbiota
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
24 Dec 2020
24 Dec 2020
Historique:
received:
08
12
2020
revised:
18
12
2020
accepted:
22
12
2020
entrez:
30
12
2020
pubmed:
31
12
2020
medline:
13
3
2021
Statut:
epublish
Résumé
We hypothesized that the role of microbiota in breast cancer relates to its influence on gut lipid metabolism. This was tested in an in vitro model combining MCF-7 and Caco-2 cells. A total of 32 women newly diagnosed for breast cancer before any treatment and 28 healthy women provided their stools. Bacterial DNA was amplified by qPCR targeting 16s rRNA specific to Bacteroidetes and Firmicutes phyla,
Identifiants
pubmed: 33374116
pii: nu13010031
doi: 10.3390/nu13010031
pmc: PMC7824055
pii:
doi:
Substances chimiques
DNA, Bacterial
0
Fatty Acids, Volatile
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ligue contre le cancer
ID : Comité 16
Organisme : Institut de Cancérologie de l'Ouest
ID : AO2016
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