Surface Layer Protein A Expressed in
Clostridioides difficile
mimotope
multiple sclerosis
myelin basic protein
surface layer protein A
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
24 Dec 2020
24 Dec 2020
Historique:
received:
26
11
2020
revised:
14
12
2020
accepted:
21
12
2020
entrez:
30
12
2020
pubmed:
31
12
2020
medline:
31
12
2020
Statut:
epublish
Résumé
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). Recent studies suggest that migration of Th1 and Th17 cells specific for enteric bacteria from the gut to the CNS may lead to the initiation and/or exacerbation of autoimmune diseases including MS. Human leukocyte antigen (HLA)-DR15 is an MHC class II (MHCII) haplotype highly associated with the development of MS that contains the two HLA-DRB* genes, DRB1*1501 (DR2b) and DRB5*0101 (DR2a). To identify enteric bacteria which harbor antigenic epitopes that activate myelin-specific T cells and drive CNS inflammation, we screened for enteric bacteria which express cross-reactive epitopes ('mimotopes') of an immunodominant myelin basic protein 89-98 (MBP
Identifiants
pubmed: 33374217
pii: microorganisms9010034
doi: 10.3390/microorganisms9010034
pmc: PMC7824458
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : New Jersey Health Foundation
ID : NJHF-PC 90-12
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