Evaluation of Metabolic Profiles of Patients with Anorexia Nervosa at Inpatient Admission, Short- and Long-Term Weight Regain-Descriptive and Pattern Analysis.

anorexia nervosa metabolites metabolomics starvation state marker trait marker

Journal

Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790

Informations de publication

Date de publication:
24 Dec 2020
Historique:
received: 14 11 2020
revised: 02 12 2020
accepted: 11 12 2020
entrez: 30 12 2020
pubmed: 31 12 2020
medline: 31 12 2020
Statut: epublish

Résumé

Acute anorexia nervosa (AN) constitutes an extreme physiological state. We aimed to detect state related metabolic alterations during inpatient admission and upon short- and long-term weight regain. In addition, we tested the hypothesis that metabolite concentrations adapt to those of healthy controls (HC) after long-term weight regain. Thirty-five female adolescents with AN and 25 female HC were recruited. Based on a targeted approach 187 metabolite concentrations were detected at inpatient admission (T

Identifiants

DOI: 10.3390/metabo11010007 PMID: 33374417 PMC: PMC7823299
pubmed: 33374417
pii: metabo11010007
doi: 10.3390/metabo11010007
pmc: PMC7823299
pii:
doi:

Types de publication

Journal Article

Langues

eng

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

Références

Lancet Diabetes Endocrinol. 2014 Jul;2(7):581-92
pubmed: 24731664
World J Biol Psychiatry. 2020 Jun;21(5):357-367
pubmed: 31161852
J Neuroimmune Pharmacol. 2015 Sep;10(3):391-5
pubmed: 26201839
Curr Protoc Bioinformatics. 2016 Sep 07;55:14.10.1-14.10.91
pubmed: 27603023
Data Brief. 2018 Jan 31;17:334-338
pubmed: 29876402
Prostaglandins Other Lipid Mediat. 2017 Sep;132:69-76
pubmed: 28232135
J Nutr. 1995 Apr;125(4):901-7
pubmed: 7722693
Metabolites. 2019 Sep 19;9(9):
pubmed: 31546923
Eur J Clin Invest. 2004 Nov;34(11):747-51
pubmed: 15530147
Biol Psychiatry. 2005 Mar 15;57(6):674-8
pubmed: 15780856
Adv Protein Chem Struct Biol. 2016;102:53-78
pubmed: 26827602
Biol Psychiatry. 2019 Feb 15;85(4):345-354
pubmed: 30446206
PLoS Med. 2018 Jan 25;15(1):e1002482
pubmed: 29370177
Eur J Clin Nutr. 2010 Apr;64(4):341-9
pubmed: 20179728
Stat Med. 1992 Jul;11(10):1305-19
pubmed: 1518992
Mol Psychiatry. 2019 Nov 7;:
pubmed: 31700192
Steroids. 2020 Jan;153:108523
pubmed: 31622616
Annu Rev Nutr. 2006;26:1-22
pubmed: 16848698
J Int Med Res. 2007 May-Jun;35(3):389-94
pubmed: 17593868
Int J Eat Disord. 2009 Mar;42(2):166-72
pubmed: 18803171
Behav Brain Res. 2017 Aug 14;332:280-287
pubmed: 28624318
Nucleic Acids Res. 2018 Jan 4;46(D1):D608-D617
pubmed: 29140435
Am J Physiol Endocrinol Metab. 2018 Oct 1;315(4):E565-E573
pubmed: 29969316
Anal Chem. 2017 Jan 3;89(1):656-665
pubmed: 27959516
Lancet Psychiatry. 2015 Dec;2(12):1099-111
pubmed: 26514083
Int J Eat Disord. 2019 Jun;52(6):611-629
pubmed: 30920679
Cell Metab. 2017 Jan 10;25(1):43-56
pubmed: 28094011
Arch Gen Psychiatry. 2011 Jul;68(7):724-31
pubmed: 21727255
Acta Paediatr. 2004 Nov;93(11):1446-8
pubmed: 15513570
Nature. 2012 Nov 15;491(7424):357-63
pubmed: 23151578
Physiol Res. 2005;54(4):443-51
pubmed: 15588144
Psychol Med. 2019 Jul;49(9):1555-1564
pubmed: 30149815
Nat Genet. 2019 Aug;51(8):1207-1214
pubmed: 31308545
Soc Psychiatry Psychiatr Epidemiol. 1998 Nov;33(11):568-78
pubmed: 9803825
Nat Commun. 2013;4:2316
pubmed: 23939267
Ann Clin Biochem. 2012 Mar;49(Pt 2):132-43
pubmed: 22349551
J Psychiatr Res. 2012 Dec;46(12):1600-9
pubmed: 22981704
Clin Nutr. 2020 Jul 31;:
pubmed: 32782162
Cas Lek Cesk. 2003;142(5):280-4
pubmed: 12920792
Eur J Clin Nutr. 1998 Sep;52(9):684-9
pubmed: 9756126
Psychiatry Clin Neurosci. 2018 May;72(5):349-361
pubmed: 29356314
Eur J Endocrinol. 2006 May;154(5):731-8
pubmed: 16645021
Int J Neuropsychopharmacol. 2014 Aug;17(8):1139-48
pubmed: 24565079
Biol Psychiatry. 2020 Mar 1;87(5):409-418
pubmed: 31635762
Physiol Res. 2009;58(4):577-81
pubmed: 18657008
Neurobiol Dis. 2009 Aug;35(2):165-76
pubmed: 19303440
Curr Protoc Bioinformatics. 2019 Dec;68(1):e86
pubmed: 31756036
J Biomed Biotechnol. 2011;2011:
pubmed: 20936179
Eur Child Adolesc Psychiatry. 2013 Feb;22 Suppl 1:S29-35
pubmed: 23224275
Nutr Res Rev. 2020 Jun;33(1):33-42
pubmed: 31434587
Mol Psychiatry. 2016 Apr;21(4):537-46
pubmed: 25824304
Ann Gen Psychiatry. 2010 Jun 25;9:29
pubmed: 20576166

Auteurs

Manuel Föcker (M)

Department of Child and Adolescent Psychiatry, University Hospital Münster, Schmeddingstraße 50, 48149 Münster, Germany.

Alexander Cecil (A)

Research Unit Molecular Endocrinology and Metabolism, Genome Analysis Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany.

Cornelia Prehn (C)

Research Unit Molecular Endocrinology and Metabolism, Genome Analysis Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany.

Jerzy Adamski (J)

Research Unit Molecular Endocrinology and Metabolism, Genome Analysis Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany.
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore.
Chair for Experimental Genetics, Technical University of Munich, 85350 Freising-Weihenstephan, Germany.

Muriel Albrecht (M)

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Wickenburgstr. 21, 45147 Essen, Germany.

Frederike Adams (F)

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Wickenburgstr. 21, 45147 Essen, Germany.

Anke Hinney (A)

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Wickenburgstr. 21, 45147 Essen, Germany.

Lars Libuda (L)

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Wickenburgstr. 21, 45147 Essen, Germany.

Judith Bühlmeier (J)

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Wickenburgstr. 21, 45147 Essen, Germany.

Johannes Hebebrand (J)

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Wickenburgstr. 21, 45147 Essen, Germany.

Triinu Peters (T)

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Wickenburgstr. 21, 45147 Essen, Germany.

Jochen Antel (J)

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Wickenburgstr. 21, 45147 Essen, Germany.

Classifications MeSH