In Vitro and In Vivo Models of Non-Alcoholic Fatty Liver Disease: A Critical Appraisal.
NAFLD
NASH
cell culture
liver-on-a-chip
mouse model
organoids
spheroids
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
24 Dec 2020
24 Dec 2020
Historique:
received:
11
11
2020
revised:
22
12
2020
accepted:
23
12
2020
entrez:
30
12
2020
pubmed:
31
12
2020
medline:
31
12
2020
Statut:
epublish
Résumé
Non-alcoholic fatty liver disease (NAFLD), including non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH), represents the hepatic manifestation of obesity and metabolic syndrome. Due to the spread of the obesity epidemic, NAFLD is becoming the most common chronic liver disease and one of the principal indications for liver transplantation. However, no pharmacological treatment is currently approved to prevent the outbreak of NASH, which leads to fibrosis and cirrhosis. Preclinical research is required to improve our knowledge of NAFLD physiopathology and to identify new therapeutic targets. In the present review, we summarize advances in NAFLD preclinical models from cellular models, including new bioengineered platforms, to in vivo models, with a particular focus on genetic and dietary mouse models. We aim to discuss the advantages and limits of these different models.
Identifiants
pubmed: 33374435
pii: jcm10010036
doi: 10.3390/jcm10010036
pmc: PMC7794936
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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