How to Build and to Protect the Neuromuscular Junction: The Role of the Glial Cell Line-Derived Neurotrophic Factor.
Amyotrophic Lateral Sclerosis
/ metabolism
Animals
Cells, Cultured
Disease Models, Animal
Dopaminergic Neurons
/ metabolism
Glial Cell Line-Derived Neurotrophic Factor
/ metabolism
Humans
Mice
Motor Neurons
Muscle, Skeletal
/ metabolism
Muscular Atrophy, Spinal
/ metabolism
Neurodegenerative Diseases
/ metabolism
Neuromuscular Junction
/ physiopathology
Rats
Substantia Nigra
/ metabolism
Synapses
/ metabolism
Synaptic Transmission
3D neuromuscular model
AD
ALS
GDNF
SMA
motor neuron diseases
neurodegenerative diseases
neuromuscular junctions
neurotrophic factors
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
24 Dec 2020
24 Dec 2020
Historique:
received:
30
10
2020
revised:
07
12
2020
accepted:
16
12
2020
entrez:
30
12
2020
pubmed:
31
12
2020
medline:
14
9
2021
Statut:
epublish
Résumé
The neuromuscular junction (NMJ) is at the crossroad between the nervous system (NS) and the muscle. Following neurotransmitter release from the motor neurons (MNs), muscle contraction occurs and movement is generated. Besides eliciting muscle contraction, the NMJ represents a site of chemical bidirectional interplay between nerve and muscle with the active participation of Schwann cells. Indeed, signals originating from the muscle play an important role in synapse formation, stabilization, maintenance and function, both in development and adulthood. We focus here on the contribution of the Glial cell line-Derived Neurotrophic Factor (GDNF) to these processes and to its potential role in the protection of the NMJ during neurodegeneration. Historically related to the maintenance and survival of dopaminergic neurons of the
Identifiants
pubmed: 33374485
pii: ijms22010136
doi: 10.3390/ijms22010136
pmc: PMC7794999
pii:
doi:
Substances chimiques
GDNF protein, human
0
Glial Cell Line-Derived Neurotrophic Factor
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : "Dipartimenti di Eccellenza 2018-2022" to the Department of Neuroscience "Rita Levi Montalcini"
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