Impact of Low-Dose Irradiation of the Lung and Heart on Toxicity and Pulmonary Function Parameters after Thoracic Radiotherapy.
lung neoplasms
organs at risk
radiation injuries
respiratory function tests
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
23 Dec 2020
23 Dec 2020
Historique:
received:
20
11
2020
revised:
14
12
2020
accepted:
19
12
2020
entrez:
30
12
2020
pubmed:
31
12
2020
medline:
31
12
2020
Statut:
epublish
Résumé
To assess the impact of (low) dose irradiation to the lungs and heart on the incidence of pneumonitis and pulmonary function changes after thoracic radiotherapy (RT). Methods/Material: Data of 62 patients treated with curative thoracic radiotherapy were analyzed. Toxicity data and pulmonary function tests (PFTs) were obtained before RT and at 6 weeks, at 12 weeks, and at 6 months after RT. PFTs included ventilation (e.g., vital capacity) and diffusion parameters (e.g., diffusion capacity for carbon monoxide (DL No statistically significant correlations between dose parameters and changes in ventilation parameters were found. There were statistically significant correlations between DL There seems to be a lasting impact of low dose irradiation to the lung as well as irradiation to the heart on the DL
Identifiants
pubmed: 33374564
pii: cancers13010022
doi: 10.3390/cancers13010022
pmc: PMC7793060
pii:
doi:
Types de publication
Journal Article
Langues
eng
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