Exosomes as Drug Delivery Systems: Endogenous Nanovehicles for Treatment of Systemic Lupus Erythematosus.
autoimmunity
drug delivery
exosomes
extracellular vesicles
microparticles
systemic lupus erythematosus
therapy
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
22 Dec 2020
22 Dec 2020
Historique:
received:
28
11
2020
revised:
17
12
2020
accepted:
18
12
2020
entrez:
30
12
2020
pubmed:
31
12
2020
medline:
31
12
2020
Statut:
epublish
Résumé
Exosomes, nanometer-sized lipid-bilayer-enclosed extracellular vesicles (EVs), have attracted increasing attention due to their inherent ability to shuttle proteins, lipids and genes between cells and their natural affinity to target cells. Their intrinsic features such as stability, biocompatibility, low immunogenicity and ability to overcome biological barriers, have prompted interest in using exosomes as drug delivery vehicles, especially for gene therapy. Evidence indicates that exosomes play roles in both immune stimulation and tolerance, regulating immune signaling and inflammation. To date, exosome-based nanocarriers delivering small molecule drugs have been developed to treat many prevalent autoimmune diseases. This review highlights the key features of exosomes as drug delivery vehicles, such as therapeutic cargo, use of targeting peptide, loading method and administration route with a broad focus. In addition, we outline the current state of evidence in the field of exosome-based drug delivery systems in systemic lupus erythematosus (SLE), evaluating exosomes derived from various cell types and engineered exosomes.
Identifiants
pubmed: 33374908
pii: pharmaceutics13010003
doi: 10.3390/pharmaceutics13010003
pmc: PMC7821934
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Instituto de Salud Carlos III
ID : PI18/01405
Organisme : Instituto de Salud Carlos III
ID : CD18/00166, Sara Borrell
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