Drug Resistance in Filarial Parasites Does Not Affect Mosquito Vectorial Capacity.

Aedes spp. Dirofilaria immitis arthropod disease transmission drug resistance extrinsic incubation period filaria macrocyclic lactones mosquito vector competence

Journal

Pathogens (Basel, Switzerland)
ISSN: 2076-0817
Titre abrégé: Pathogens
Pays: Switzerland
ID NLM: 101596317

Informations de publication

Date de publication:
22 Dec 2020
Historique:
received: 15 11 2020
revised: 15 12 2020
accepted: 18 12 2020
entrez: 30 12 2020
pubmed: 31 12 2020
medline: 31 12 2020
Statut: epublish

Résumé

Parasite drug resistance presents a major obstacle to controlling and eliminating vector-borne diseases affecting humans and animals. While vector-borne disease dynamics are affected by factors related to parasite, vertebrate host and vector, research on drug resistance in filarial parasites has primarily focused on the parasite and vertebrate host, rather than the mosquito. However, we expect that the physiological costs associated with drug resistance would reduce the fitness of drug-resistant vs. drug-susceptible parasites in the mosquito wherein parasites are not exposed to drugs. Here we test this hypothesis using four isolates of the dog heartworm (

Identifiants

pubmed: 33375024
pii: pathogens10010002
doi: 10.3390/pathogens10010002
pmc: PMC7822010
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : U.S. Department of Energy Financial Assistance Award
ID : DE-EM0004391

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Auteurs

Erik Neff (E)

Savannah River Ecology Laboratory, University of Georgia, Drawer E, Aiken, SC 29802, USA.

Christopher C Evans (CC)

Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.

Pablo D Jimenez Castro (PD)

Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Grupo de Parasitología Veterinaria, Universidad Nacional de Colombia, Bogotá 11001000, Colombia.

Ray M Kaplan (RM)

Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.

Guha Dharmarajan (G)

Savannah River Ecology Laboratory, University of Georgia, Drawer E, Aiken, SC 29802, USA.

Classifications MeSH