Insights into the Membranolytic Activity of Antimalarial Drug-Cell Penetrating Peptide Conjugates.
antimalarial
biophysics
cell penetrating peptide
dynamic light scattering
haemolysis
lipid membranes
surface plasmon resonance
Journal
Membranes
ISSN: 2077-0375
Titre abrégé: Membranes (Basel)
Pays: Switzerland
ID NLM: 101577807
Informations de publication
Date de publication:
22 Dec 2020
22 Dec 2020
Historique:
received:
01
12
2020
revised:
15
12
2020
accepted:
17
12
2020
entrez:
30
12
2020
pubmed:
31
12
2020
medline:
31
12
2020
Statut:
epublish
Résumé
Conjugation of TP10, a cell-penetrating peptide with intrinsic antimalarial activity, to the well-known antimalarial drugs chloroquine and primaquine has been previously shown to enhance the peptide's action against, respectively, blood- and liver-stage malaria parasites. Yet, this was achieved at the cost of a significant increase in haemolytic activity, as fluorescence microscopy and flow cytometry studies showed the conjugates to be more haemolytic for non-infected than for
Identifiants
pubmed: 33375073
pii: membranes11010004
doi: 10.3390/membranes11010004
pmc: PMC7822033
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Fundação para a Ciência e a Tecnologia
ID : UIDB/50006/2020
Organisme : Fundação para a Ciência e a Tecnologia
ID : IF/00092/2014/CP1255/CT0004
Organisme : Fundação para a Ciência e a Tecnologia
ID : PD/BD/106035/2015
Références
Mol Biochem Parasitol. 1985 Mar;14(3):313-22
pubmed: 3887158
Biochem J. 2014 Jan 1;457(1):1-18
pubmed: 24325549
Chem Phys Lipids. 2006 Jan;139(1):11-9
pubmed: 16253216
J Pharm Sci. 2003 Jan;92(1):45-57
pubmed: 12486681
Biochem J. 1991 Feb 15;274 ( Pt 1):121-32
pubmed: 2001227
Bioorg Med Chem Lett. 2017 Sep 1;27(17):4190-4193
pubmed: 28733082
Eur J Pharm Biopharm. 2013 Nov;85(3 Pt A):597-603
pubmed: 23523541
Blood. 1987 Feb;69(2):401-7
pubmed: 3542079
Malar J. 2019 Mar 22;18(1):93
pubmed: 30902052
Medchemcomm. 2018 Nov 16;10(2):221-226
pubmed: 30881610
Sci Transl Med. 2012 May 23;4(135):135ra64
pubmed: 22623740
Microbiol Rev. 1979 Dec;43(4):453-95
pubmed: 94424
Int J Mol Sci. 2020 Jun 30;21(13):
pubmed: 32630159
Sensors (Basel). 2010;10(8):7323-46
pubmed: 22163605
J Colloid Interface Sci. 2014 Oct 1;431:24-30
pubmed: 24980622
Parasitol Res. 2002 Jan;88(1):16-20
pubmed: 11822732
Bull World Health Organ. 1977;55(2-3):237-48
pubmed: 412602
Nature. 2002 Oct 3;419(6906):520-6
pubmed: 12368866
Science. 1986 Apr 4;232(4746):102-4
pubmed: 3006251
Biochim Biophys Acta. 2016 Apr;1858(4):872-82
pubmed: 26850736
Mol Biochem Parasitol. 1990 Jan 1;38(1):105-12
pubmed: 2157152
Mol Pharmacol. 2006 Apr;69(4):1115-24
pubmed: 16387795
Biochem Biophys Res Commun. 1987 Mar 13;143(2):461-6
pubmed: 3551952
Antimicrob Agents Chemother. 2008 Sep;52(9):3414-7
pubmed: 18519720
Molecules. 2019 Dec 12;24(24):
pubmed: 31842498
J Med Chem. 2013 Jan 24;56(2):556-67
pubmed: 23273038
Langmuir. 2011 Sep 6;27(17):10847-58
pubmed: 21790169
Eur J Biochem. 1984 Jan 2;138(1):9-37
pubmed: 6692818
J Cell Biol. 1991 Jan;112(2):267-77
pubmed: 1988461
Annu Rev Microbiol. 2013;67:243-69
pubmed: 23808341
Vet Pathol. 1987 Nov;24(6):471-6
pubmed: 3331858
Cell Physiol Biochem. 2002;12(5-6):373-84
pubmed: 12438774
Methods Mol Biol. 2013;974:55-71
pubmed: 23404272