Restoration of Sarcoplasmic Reticulum Ca

Age Factors Aminoquinolines / administration & dosage Animals Benzamides / administration & dosage Enzyme Activation / drug effects Injections, Intraperitoneal MAP Kinase Signaling System / drug effects Male Mice, Inbred C57BL Mitochondria, Muscle / drug effects Muscle Weakness / physiopathology Muscle, Skeletal / drug effects Muscular Atrophy / metabolism Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Reactive Oxygen Species / metabolism Sarcoplasmic Reticulum Calcium-Transporting ATPases / metabolism Uncoupling Protein 1 / metabolism
sarcopenia sarcoplasmic reticulum calcium-transporting ATPase skeletal muscle

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
22 Dec 2020
Historique:
received: 25 11 2020
revised: 18 12 2020
accepted: 19 12 2020
entrez: 30 12 2020
pubmed: 31 12 2020
medline: 30 3 2021
Statut: epublish

Résumé

Sarcopenia has a significant negative impact on healthspan in the elderly and effective pharmacologic interventions remain elusive. We have previously demonstrated that sarcopenia is associated with reduced activity of the sarcoplasmic reticulum Ca

Identifiants

DOI: 10.3390/ijms22010037 PMID: 33375170 PMC: PMC7792969
pubmed: 33375170
pii: ijms22010037
doi: 10.3390/ijms22010037
pmc: PMC7792969
pii:
doi:

Substances chimiques

Aminoquinolines 0
Benzamides 0
CDN1163 0
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha 0
Ppargc1a protein, mouse 0
Reactive Oxygen Species 0
Uncoupling Protein 1 0
Sarcoplasmic Reticulum Calcium-Transporting ATPases EC 3.6.3.8

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : VA merit grant
ID : I01BX004453-01A1
Organisme : AFAR
ID : Irene Diamond Postdoctoral award

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Auteurs

Rizwan Qaisar (R)

Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, UAE.

Gavin Pharaoh (G)

Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.

Shylesh Bhaskaran (S)

Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.

Hongyang Xu (H)

Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.

Rojina Ranjit (R)

Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.

Jan Bian (J)

Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.

Bumsoo Ahn (B)

Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.

Constantin Georgescu (C)

Division of Genomics and Data Sciences, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.

Jonathan D Wren (JD)

Division of Genomics and Data Sciences, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.

Holly Van Remmen (H)

Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.
Oklahoma City VA Medical Center, Oklahoma City, OK 73104, USA.

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Facteurs âges › Restoration of Sarcoplasmic Reticulum Ca
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Aminoquinoléines › Restoration of Sarcoplasmic Reticulum Ca
questionsmedicales.fr › Eucaryotes › Animaux › Restoration of Sarcoplasmic Reticulum Ca
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Benzoates › Benzamides › Restoration of Sarcoplasmic Reticulum Ca
questionsmedicales.fr › Métabolisme › Activation enzymatique › Restoration of Sarcoplasmic Reticulum Ca
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Injections › Injections péritoneales › Restoration of Sarcoplasmic Reticulum Ca
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Système de signalisation des MAP kinases › Restoration of Sarcoplasmic Reticulum Ca
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Restoration of Sarcoplasmic Reticulum Ca
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Mitochondries du muscle › Restoration of Sarcoplasmic Reticulum Ca
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Manifestations neuromusculaires › Faiblesse musculaire › Restoration of Sarcoplasmic Reticulum Ca
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Muscles squelettiques › Restoration of Sarcoplasmic Reticulum Ca
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Manifestations neuromusculaires › Amyotrophie › Restoration of Sarcoplasmic Reticulum Ca
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Coactivateurs de récepteurs nucléaires › Coactivateur 1-alpha du récepteur gamma activé par les proliférateurs de peroxysomes › Restoration of Sarcoplasmic Reticulum Ca
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Restoration of Sarcoplasmic Reticulum Ca
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › P-type ATPases › Calcium-Transporting ATPases › Sarcoplasmic Reticulum Calcium-Transporting ATPases › Restoration of Sarcoplasmic Reticulum Ca
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Protéines de transport de la membrane mitochondriale › Protéines de découplage mitochondrial › Protéine-1 de découplage › Restoration of Sarcoplasmic Reticulum Ca