A Conformation Variant of p53 Combined with Machine Learning Identifies Alzheimer Disease in Preclinical and Prodromal Stages.
Alzheimer’s disease
blood-based biomarker
conformation variant of p53
machine learning
β-amyloid
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
26 Dec 2020
26 Dec 2020
Historique:
received:
20
11
2020
revised:
22
12
2020
accepted:
24
12
2020
entrez:
30
12
2020
pubmed:
31
12
2020
medline:
31
12
2020
Statut:
epublish
Résumé
Early diagnosis of Alzheimer's disease (AD) is a crucial starting point in disease management. Blood-based biomarkers could represent a considerable advantage in providing AD-risk information in primary care settings. Here, we report new data for a relatively unknown blood-based biomarker that holds promise for AD diagnosis. We evaluate a p53-misfolding conformation recognized by the antibody 2D3A8, also named Unfolded p53 (U-p53
Identifiants
pubmed: 33375220
pii: jpm11010014
doi: 10.3390/jpm11010014
pmc: PMC7823360
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : DIADEM s.r.l.
ID : to D.U.
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : to D.U. and M.Me
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