Pathophysiology and Treatment of Pruritus in Elderly.
elderly
ion channel
itch
neurotransmission pathophysiology of itch
pruritogen
senile pruritus
treatment of itch
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
26 Dec 2020
26 Dec 2020
Historique:
received:
30
11
2020
revised:
16
12
2020
accepted:
24
12
2020
entrez:
30
12
2020
pubmed:
31
12
2020
medline:
8
9
2021
Statut:
epublish
Résumé
Pruritus is a relatively common symptom that anyone can experience at any point in their life and is more common in the elderly. Pruritus in elderly can be defined as chronic pruritus in a person over 65 years old. The pathophysiology of pruritus in elderly is still unclear, and the quality of life is reduced. Generally, itch can be clinically classified into six types: Itch caused by systemic diseases, itch caused by skin diseases, neuropathic pruritus, psychogenic pruritus, pruritus with multiple factors, and from unknown causes. Senile pruritus can be defined as a chronic pruritus of unknown origin in elderly people. Various neuronal mediators, signaling mechanisms at neuronal terminals, central and peripheral neurotransmission pathways, and neuronal sensitizations are included in the processes causing itch. A variety of therapies are used and several novel drugs are being developed to relieve itch, including systemic and topical treatments.
Identifiants
pubmed: 33375325
pii: ijms22010174
doi: 10.3390/ijms22010174
pmc: PMC7795219
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Research Foundation of Korea (NRF, funded by the South Korean government (MSIT)
ID : 2017R1A2B4006252
Organisme : National Research Foundation of Korea (NRF, funded by the South Korean government (MSIT)
ID : 2018R1C1B6007998
Organisme : The Korea Healthcare Technology R&D Project (funded by the Ministry of Health and Welfare)
ID : HI17C0597
Organisme : Korea Centers for Disease Control and Prevention (KCDC)
ID : 2020-ER6714-00
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