Challenges in Bone Tissue Regeneration: Stem Cell Therapy, Biofunctionality and Antimicrobial Properties of Novel Materials and Its Evolution.
Animals
Anti-Bacterial Agents
/ chemistry
Bone Regeneration
/ physiology
Cell Culture Techniques
/ methods
Ceramics
/ chemistry
High-Throughput Screening Assays
/ instrumentation
Humans
Mesenchymal Stem Cells
/ cytology
Metals
/ chemistry
Osteogenesis
/ drug effects
Polymers
/ chemistry
Stem Cell Transplantation
/ methods
Tissue Engineering
/ methods
Tissue Scaffolds
/ chemistry
Wound Healing
/ drug effects
antimicrobial materials
bone tissue engineering
critical large bone defects
high-throughput screening systems
mesenchymal stem cells
stem cell therapy
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 Dec 2020
27 Dec 2020
Historique:
received:
30
11
2020
revised:
21
12
2020
accepted:
23
12
2020
entrez:
30
12
2020
pubmed:
31
12
2020
medline:
1
4
2021
Statut:
epublish
Résumé
An aging population leads to increasing demand for sustained quality of life with the aid of novel implants. Patients expect fast healing and few complications after surgery. Increased biofunctionality and antimicrobial behavior of implants, in combination with supportive stem cell therapy, can meet these expectations. Recent research in the field of bone implants and the implementation of autologous mesenchymal stem cells in the treatment of bone defects is outlined and evaluated in this review. The article highlights several advantages, limitations and advances for metal-, ceramic- and polymer-based implants and discusses the future need for high-throughput screening systems used in the evaluation of novel developed materials and stem cell therapies. Automated cell culture systems, microarray assays or microfluidic devices are required to efficiently analyze the increasing number of new materials and stem cell-assisted therapies. Approaches described in the literature to improve biocompatibility, biofunctionality and stem cell differentiation efficiencies of implants range from the design of drug-laden nanoparticles to chemical modification and the selection of materials that mimic the natural tissue. Combining suitable implants with mesenchymal stem cell treatment promises to shorten healing time and increase treatment success. Most research studies focus on creating antibacterial materials or modifying implants with antibacterial coatings in order to address the increasing number of complications after surgeries that are mostly caused by bacterial infections. Moreover, treatment of multiresistant pathogens will pose even bigger challenges in hospitals in the future, according to the World Health Organization (WHO). These antibacterial materials will help to reduce infections after surgery and the number of antibiotic treatments that contribute to the emergence of new multiresistant pathogens, whilst the antibacterial implants will help reduce the amount of antibiotics used in clinical treatment.
Identifiants
pubmed: 33375478
pii: ijms22010192
doi: 10.3390/ijms22010192
pmc: PMC7794985
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Metals
0
Polymers
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Europäischer Fonds für regionale Entwicklung - EFRE) in the program "Interreg V Oberrhein
ID : 5115 / 3.17
Références
Tissue Eng Part A. 2018 Nov;24(21-22):1693-1703
pubmed: 29792383
J Inorg Biochem. 2017 Jun;171:100-107
pubmed: 28380345
Acta Biomater. 2016 Dec;46:112-128
pubmed: 27686039
Biomacromolecules. 2003 Nov-Dec;4(6):1457-65
pubmed: 14606868
World J Stem Cells. 2013 Oct 26;5(4):136-48
pubmed: 24179602
Anal Chim Acta. 2016 Jan 15;903:36-50
pubmed: 26709297
Anal Chim Acta. 2013 Jul 17;787:24-35
pubmed: 23830418
J Mater Chem B. 2020 Sep 30;8(37):8695-8701
pubmed: 32857090
Arch Toxicol. 2015 Sep;89(9):1469-95
pubmed: 25975987
Injury. 2011 Sep;42 Suppl 2:S77-81
pubmed: 21724186
Arch Oral Biol. 2007 Jan;52(1):64-73
pubmed: 17049335
Biomaterials. 2011 Sep;32(27):6362-73
pubmed: 21658758
Toxicol Appl Pharmacol. 2019 Oct 1;380:114706
pubmed: 31400414
Integr Biol (Camb). 2014 May;6(5):555-63
pubmed: 24676392
Biomaterials. 2010 Dec;31(34):8989-95
pubmed: 20828808
Mater Sci Eng C Mater Biol Appl. 2019 May;98:1073-1086
pubmed: 30812991
Blood. 2010 Feb 25;115(8):1549-53
pubmed: 20032501
Int J Nanomedicine. 2019 May 07;14:3331-3343
pubmed: 31123401
Bone Miner. 1994 Oct;27(1):57-67
pubmed: 7849547
Materials (Basel). 2020 Apr 13;13(8):
pubmed: 32295064
ACS Biomater Sci Eng. 2019 Jun 10;5(6):3131-3138
pubmed: 33405545
Stem Cell Res Ther. 2017 Jun 24;8(1):148
pubmed: 28646917
J Biomed Mater Res A. 2003 Dec 1;67(3):813-27
pubmed: 14613229
Nanomedicine. 2018 Jul;14(5):1719-1731
pubmed: 29665441
Biofabrication. 2017 Nov 30;10(1):015002
pubmed: 29083312
Nanotechnology. 2005 Oct;16(10):2346-53
pubmed: 20818017
Biomaterials. 1996 Jul;17(14):1443-9
pubmed: 8830973
Biomaterials. 2005 Jun;26(16):3173-85
pubmed: 15603812
J Surg Res. 2018 Mar;223:115-122
pubmed: 29433862
Biomaterials. 2006 Mar;27(8):1542-9
pubmed: 16165205
Acta Biomater. 2017 Aug;58:214-224
pubmed: 28578107
Bone Miner. 1993 Dec;23(3):223-32
pubmed: 8148667
Biomaterials. 2000 Dec;21(23):2347-59
pubmed: 11055282
Biomaterials. 2010 Mar;31(8):2216-28
pubmed: 20056271
Chem Eng J. 2018 May 15;340:9-14
pubmed: 31384170
Clin Orthop Relat Res. 2002 Feb;(395):81-98
pubmed: 11937868
J Colloid Interface Sci. 2019 Oct 1;553:382-389
pubmed: 31226629
Eur Cell Mater. 2011 May 15;21:407-29; discussion 429
pubmed: 21604242
Sensors (Basel). 2019 Apr 10;19(7):
pubmed: 30974880
J Biomed Mater Res B Appl Biomater. 2020 Aug;108(6):2546-2559
pubmed: 32061059
J Microbiol Methods. 2013 Sep;94(3):311-6
pubmed: 23892060
Cytotherapy. 2013 Jul;15(7):753-9
pubmed: 23602595
Bioact Mater. 2017 Jun 07;2(4):224-247
pubmed: 29744432
Perm J. 2019;24:
pubmed: 31852052
Anal Chim Acta. 2019 Sep 13;1071:36-43
pubmed: 31128753
Pathologe. 2010 Oct;31 Suppl 2:138-46
pubmed: 20711587
Appl Environ Microbiol. 2008 Jun;74(12):3764-73
pubmed: 18456858
Acta Biomater. 2018 Oct 1;79:265-275
pubmed: 30125670
Nat Biotechnol. 2017 Apr 11;35(4):312-314
pubmed: 28398331
SLAS Discov. 2017 Jan;22(1):40-50
pubmed: 27628690
Biosens Bioelectron. 2015 May 15;67:379-85
pubmed: 25194237
Acta Biomater. 2018 Aug;76:275-282
pubmed: 29898419
J Mater Sci Mater Med. 2010 Jan;21(1):131-7
pubmed: 19701720
Int J Nanomedicine. 2014 Nov 17;9:5307-16
pubmed: 25429217
Biomaterials. 2015 Oct;67:93-103
pubmed: 26210176
J Neuroinflammation. 2013 Aug 23;10:106
pubmed: 23971414
J Biomed Mater Res. 2000 Dec 15;52(4):662-8
pubmed: 11033548
J Oral Maxillofac Surg. 2008 Dec;66(12):2488-92
pubmed: 19022128
Stem Cell Reports. 2019 Aug 13;13(2):262-273
pubmed: 31303506
Int J Pharm. 2013 Jan 20;440(2):195-206
pubmed: 22884778
J Mater Sci Mater Med. 2005 May;16(5):467-75
pubmed: 15875258
Anticancer Res. 2004 Nov-Dec;24(6):3743-8
pubmed: 15736406
Nanomedicine. 2018 Oct;14(7):2061-2073
pubmed: 29964218
Curr Osteoporos Rep. 2013 Jun;11(2):72-82
pubmed: 23605904
J Biomech. 2018 Jun 6;74:180-186
pubmed: 29773424
Tissue Eng Part A. 2010 Feb;16(2):653-62
pubmed: 19754224
J Craniofac Surg. 1997 Mar;8(2):87-91
pubmed: 10332272
Adv Colloid Interface Sci. 2017 Dec;250:185-194
pubmed: 28950985
Mol Cell. 2019 Jan 3;73(1):130-142.e5
pubmed: 30472192
Colloids Surf B Biointerfaces. 2019 Sep 1;181:349-359
pubmed: 31158697
Hand Clin. 2012 Nov;28(4):457-68
pubmed: 23101596
Adv Healthc Mater. 2019 Mar;8(5):e1801465
pubmed: 30673161
Nanomedicine. 2017 Jul;13(5):1809-1819
pubmed: 28259801
Int J Mol Sci. 2018 Mar 12;19(3):
pubmed: 29534546
Acta Biomater. 2016 Nov;45:110-120
pubmed: 27612960
Int J Mol Sci. 2018 Aug 09;19(8):
pubmed: 30096912
J Steroid Biochem Mol Biol. 2009 Aug;116(1-2):86-92
pubmed: 19460432
Electrophoresis. 2013 Oct;34(19):2836-47
pubmed: 23857076
J Biomed Mater Res B Appl Biomater. 2015 Jul;103(5):1044-9
pubmed: 25230382
J Orthop Surg Res. 2018 Feb 12;13(1):33
pubmed: 29433544
Mater Sci Eng C Mater Biol Appl. 2014 Oct;43:472-80
pubmed: 25175238
J Orthop Res. 2003 May;21(3):420-31
pubmed: 12706014
Biomaterials. 2009 Feb;30(6):1045-55
pubmed: 19022500
Biomaterials. 2018 Oct;181:15-34
pubmed: 30071379
Mater Sci Eng C Mater Biol Appl. 2019 Nov;104:109895
pubmed: 31500047
Assay Drug Dev Technol. 2008 Oct;6(5):637-57
pubmed: 19035846
J Mech Behav Biomed Mater. 2020 Mar;103:103532
pubmed: 31756563
Nanomedicine. 2018 Jan;14(1):153-164
pubmed: 28965979
J Mech Behav Biomed Mater. 2020 Mar;103:103576
pubmed: 32090905
Tissue Eng Part A. 2015 Feb;21(3-4):594-602
pubmed: 25251779
Biomed Pharmacother. 2019 Jan;109:573-581
pubmed: 30399593
Int J Mol Sci. 2011;12(3):1936-63
pubmed: 21673932
ACS Biomater Sci Eng. 2020 Mar 9;6(3):1500-1509
pubmed: 33455392
Carbohydr Polym. 2020 Oct 1;245:116522
pubmed: 32718626
Biomacromolecules. 2019 Sep 9;20(9):3366-3374
pubmed: 31429537
Mater Sci Eng C Mater Biol Appl. 2019 Jul;100:297-307
pubmed: 30948064
J Orthop Translat. 2015 Jun 16;3(3):95-104
pubmed: 30035046
Cells Tissues Organs. 2017;204(2):59-83
pubmed: 28647733
J Biol Eng. 2017 Oct 16;11:31
pubmed: 29046717
J Biomater Sci Polym Ed. 2018 May - Jun;29(7-9):894-906
pubmed: 28934914
J Control Release. 2019 Oct;311-312:257-272
pubmed: 31494183
Methods. 2018 Jan 1;132:57-65
pubmed: 28716510
Int J Mol Sci. 2019 Mar 25;20(6):
pubmed: 30934541
Drug Discov Today. 2014 Jun;19(6):794-800
pubmed: 24508820
Injury. 2009 Nov;40 Suppl 4:S95-102
pubmed: 19895960
Cell Mol Life Sci. 2020 Jul;77(14):2771-2794
pubmed: 31965214
Int J Stem Cells. 2019 Mar 30;12(1):84-94
pubmed: 30836724
Biomaterials. 2005 Oct;26(30):5983-90
pubmed: 15894370
Biophys J. 2000 Oct;79(4):2002-9
pubmed: 11023904
Nat Protoc. 2011 Jan;6(1):105-10
pubmed: 21212786
Biomol Detect Quantif. 2015 Jun 06;4:22-32
pubmed: 27077035
Biotechnol Bioeng. 2013 May;110(5):1444-55
pubmed: 23192318
Cell Tissue Res. 2017 May;368(2):229-238
pubmed: 27425852
Bull World Health Organ. 2016 Sep 1;94(9):638-639
pubmed: 27708467
Acta Biomater. 2016 Sep 15;42:389-399
pubmed: 27326916
Biomaterials. 2017 Jan;113:158-169
pubmed: 27815999
Differentiation. 2019 May - Jun;107:24-34
pubmed: 31152959
Proteomics. 2015 Sep;15(18):3169-74
pubmed: 25504905
Injury. 2011 Jun;42(6):562-8
pubmed: 21489533
Anal Chim Acta. 2018 Feb 25;1001:1-17
pubmed: 29291790
Orthop Surg. 2017 Feb;9(1):13-19
pubmed: 28276640
Blood. 2005 Dec 15;106(13):4057-65
pubmed: 16118325
Eukaryot Cell. 2005 Apr;4(4):703-15
pubmed: 15821130
Biosens Bioelectron. 2019 Dec 1;145:111730
pubmed: 31590074
Sci Transl Med. 2018 Jan 17;10(424):
pubmed: 29343626
Biochim Biophys Acta. 1999 Dec 15;1462(1-2):55-70
pubmed: 10590302
Mater Sci Eng C Mater Biol Appl. 2017 Feb 1;71:84-92
pubmed: 27987780
Biofabrication. 2016 Jan 07;8(1):015003
pubmed: 26741113
Lancet Infect Dis. 2019 Jan;19(1):56-66
pubmed: 30409683
Biomaterials. 2010 Jan;31(2):187-98
pubmed: 19815273
Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6139-44
pubmed: 21444814
Bioorg Med Chem. 2008 Oct 15;16(20):9176-83
pubmed: 18823786
Acta Biomater. 2017 Oct 1;61:1-20
pubmed: 28501710
J Agric Food Chem. 2006 Sep 6;54(18):6629-33
pubmed: 16939319
Mater Sci Eng C Mater Biol Appl. 2017 Apr 1;73:347-356
pubmed: 28183618
Nanomedicine. 2019 Oct;21:102040
pubmed: 31228602
Biomaterials. 2019 Dec;225:119537
pubmed: 31614290
Curr Stem Cell Res Ther. 2010 Mar;5(1):81-93
pubmed: 19951252
Cancer Res. 2007 Oct 1;67(19):9142-9
pubmed: 17909019
Biomaterials. 2005 Oct;26(29):5872-8
pubmed: 15949553
PLoS Med. 2016 Nov 29;13(11):e1002184
pubmed: 27898664
Biosens Bioelectron. 2015 Jan 15;63:218-231
pubmed: 25105943
Injury. 2012 Mar;43(3):266-71
pubmed: 21371707
Eur Cell Mater. 2014 Jun 08;27:332-49
pubmed: 24908426
J Korean Assoc Oral Maxillofac Surg. 2014 Apr;40(2):50-60
pubmed: 24868501
Biotechnol Bioeng. 2011 Jan;108(1):163-74
pubmed: 20824673
Bioact Mater. 2020 Jan 15;5(1):82-91
pubmed: 31956737
Shock. 2016 Dec;46(6):597-608
pubmed: 27454373
Acta Biomater. 2017 Nov;63:369-382
pubmed: 28882757
Bone Rep. 2019 Apr 11;10:100205
pubmed: 31193299
Phytother Res. 2006 Nov;20(11):952-60
pubmed: 16906639
Exp Mol Med. 2018 Apr 20;50(4):1-15
pubmed: 29674661
Biomaterials. 2019 Mar;196:67-79
pubmed: 29602560
Adv Colloid Interface Sci. 2004 Jun 30;110(1-2):5-17
pubmed: 15142821
Acta Biomater. 2016 Apr 01;34:1-20
pubmed: 26361719
Cytotherapy. 2013 Nov;15(11):1307-8
pubmed: 24094485
Clin Orthop Relat Res. 1986 Apr;(205):299-308
pubmed: 3084153
Mater Sci Eng C Mater Biol Appl. 2020 Mar;108:110489
pubmed: 31923957
Colloids Surf B Biointerfaces. 2018 Apr 1;164:396-405
pubmed: 29427946
J Control Release. 2017 May 28;254:65-74
pubmed: 28363521
J Colloid Interface Sci. 2004 Jul 1;275(1):177-82
pubmed: 15158396
Injury. 2010 Jul;41(7):731-8
pubmed: 20233614
Mater Sci Eng C Mater Biol Appl. 2019 Nov;104:109960
pubmed: 31500051
Acta Biomater. 2017 Sep 1;59:12-20
pubmed: 28666885
Cryobiology. 2015 Feb;70(1):1-8
pubmed: 25445570
Curr Stem Cell Res Ther. 2016;11(3):216-25
pubmed: 25986621