Quantitative Color Fundus Autofluorescence in Patients with Diabetes Mellitus.
advanced glycation end products
autofluorescence
diabetes mellitus
diabetic macular edema
diabetic retinopathy
green-emitting fluorophores
lipofuscin
retinal inflammation
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
25 Dec 2020
25 Dec 2020
Historique:
received:
28
10
2020
revised:
07
12
2020
accepted:
19
12
2020
entrez:
30
12
2020
pubmed:
31
12
2020
medline:
31
12
2020
Statut:
epublish
Résumé
A new short wavelength confocal blue-light 450 nm-fundus autofluorescence (color-FAF) allows for visualization of minor fluorophores (e.g., advanced glycation end products, AGEs), besides lipofuscin. The aim of the present pilot study was to quantitatively evaluate color-FAF in patients with diabetes mellitus (DM) and to correlate these data with different stages of retinal disease severity. Optical coherence tomography and color-FAF images of 193 patients/eyes and 18 controls were analyzed using a custom software for quantification of the long (red) and short (green) wavelength components of the emission spectrum (REFC/GEFC). Measurements were performed in nine quadrants of the 6-mm ETDRS macular grid. Foveal GEFC and REFC intensities were higher in patients with DM compared to controls (
Identifiants
pubmed: 33375699
pii: jcm10010048
doi: 10.3390/jcm10010048
pmc: PMC7796312
pii:
doi:
Types de publication
Journal Article
Langues
eng
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