Quinazolin-4(3H)-one based agents bearing thiadiazole-urea: Synthesis and evaluation of anti-proliferative and antiangiogenic activity.
Angiogenesis Inhibitors
/ chemical synthesis
Antineoplastic Agents
/ chemical synthesis
Cell Line, Tumor
Cell Proliferation
/ drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Molecular Structure
Quinazolinones
/ chemical synthesis
Structure-Activity Relationship
Thiadiazoles
/ chemistry
Urea
/ chemistry
Apoptotic effects
CAM assay
PC3 cells
Sorafenib
VEGFR-2
Western blotting
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
25
08
2020
revised:
03
11
2020
accepted:
09
12
2020
pubmed:
31
12
2020
medline:
22
9
2021
entrez:
30
12
2020
Statut:
ppublish
Résumé
A series of quinazolin-4(3H)-one based agents containing thiadiazole-urea were designed, synthesized, and biologically evaluated. The proliferation rate of PC3 cells was moderately reduced by compound 9f (IC
Identifiants
pubmed: 33376012
pii: S0045-2068(20)31851-4
doi: 10.1016/j.bioorg.2020.104553
pii:
doi:
Substances chimiques
Angiogenesis Inhibitors
0
Antineoplastic Agents
0
Quinazolinones
0
Thiadiazoles
0
Urea
8W8T17847W
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104553Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.