Presence of Titanium and Toxic Effects Observed in Rat Lungs, Kidneys, and Central Nervous System in vivo and in Cultured Astrocytes in vitro on Exposure by Titanium Dioxide Nanorods.
apoptosis
nanoparticles
neuro-functional changes
tissue damage
toxicity
Journal
International journal of nanomedicine
ISSN: 1178-2013
Titre abrégé: Int J Nanomedicine
Pays: New Zealand
ID NLM: 101263847
Informations de publication
Date de publication:
2020
2020
Historique:
received:
28
08
2020
accepted:
11
11
2020
entrez:
30
12
2020
pubmed:
31
12
2020
medline:
7
1
2021
Statut:
epublish
Résumé
Non-spherical titanium dioxide (TiO Anatase form TiO The treated astrocytes showed loss of viability without detectable apoptosis. In rats, TiO Based on localization of the visualized nanorods, on neuro-functional changes, and on literature data, the toxic mechanism involved mitochondrial damage, oxidative stress, and apoptotic cell death. These indicate potential human toxicity and occupational risk in case of exposure to rod-shaped TiO
Sections du résumé
BACKGROUND
BACKGROUND
Non-spherical titanium dioxide (TiO
MATERIALS AND METHODS
METHODS
Anatase form TiO
RESULTS
RESULTS
The treated astrocytes showed loss of viability without detectable apoptosis. In rats, TiO
CONCLUSION
CONCLUSIONS
Based on localization of the visualized nanorods, on neuro-functional changes, and on literature data, the toxic mechanism involved mitochondrial damage, oxidative stress, and apoptotic cell death. These indicate potential human toxicity and occupational risk in case of exposure to rod-shaped TiO
Identifiants
pubmed: 33376320
doi: 10.2147/IJN.S275937
pii: 275937
pmc: PMC7765755
doi:
Substances chimiques
titanium dioxide
15FIX9V2JP
Titanium
D1JT611TNE
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
9939-9960Informations de copyright
© 2020 Papp et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work. This work is partially based on the PhD thesis of Tamara Horváth (Szeged, 2019).
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