Fibrosis following Acute Skeletal Muscle Injury: Mitigation and Reversal Potential in the Clinic.
Journal
Journal of sports medicine (Hindawi Publishing Corporation)
ISSN: 2356-7651
Titre abrégé: J Sports Med (Hindawi Publ Corp)
Pays: United States
ID NLM: 101633176
Informations de publication
Date de publication:
2020
2020
Historique:
received:
12
05
2020
accepted:
14
07
2020
entrez:
30
12
2020
pubmed:
31
12
2020
medline:
31
12
2020
Statut:
epublish
Résumé
Skeletal muscle injuries occur often in athletics and in daily life. In minor injuries, muscles are able to regenerate completely and recover their functional capabilities. However, in the case of severe injuries, the injured muscle cannot recover to a functional level because of the formation of fibrous scar tissue. The physical barrier of scars is significantly challenged in both research and clinical treatment. Fibrous scar tissue not only limits cells' migration, but also contributes to normal tissue biomechanical properties. This scar formation creates an unsuitable environment for tissue structure resulting in frequent pain. Antifibrosis treatment is one of the major strategies used to augment muscle regeneration and accelerate its functional recovery. This review will discuss the currently available methods for improving muscle regeneration with a specific focus on antifibrosis applications. We also discussed several novel hypotheses and clinical applications in muscle fibrosis treatment currently in practice.
Identifiants
pubmed: 33376749
doi: 10.1155/2020/7059057
pmc: PMC7745048
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
7059057Informations de copyright
Copyright © 2020 Tyler Gardner et al.
Déclaration de conflit d'intérêts
The authors declare that there are no financial conflicts regarding the publication of this article.
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