Modulation of the liver immune microenvironment by the adeno-associated virus serotype 8 gene therapy vector.
Adeno-associated virus-8
gene therapy
immune response
inflammation
intravital imaging
liver
Journal
Molecular therapy. Methods & clinical development
ISSN: 2329-0501
Titre abrégé: Mol Ther Methods Clin Dev
Pays: United States
ID NLM: 101624857
Informations de publication
Date de publication:
12 Mar 2021
12 Mar 2021
Historique:
received:
06
07
2020
accepted:
28
10
2020
entrez:
30
12
2020
pubmed:
31
12
2020
medline:
31
12
2020
Statut:
epublish
Résumé
Adeno-associated viruses (AAVs) are emerging as one of the vehicles of choice for gene therapy. However, the potential immunogenicity of these vectors is a major limitation of their use, leading to the necessity of a better understanding of how viral vectors engage the innate immune system. In this study, we demonstrate the immune response mediated by an AAV vector in a mouse model. Mice were infected intravenously with 4 × 10
Identifiants
pubmed: 33376758
doi: 10.1016/j.omtm.2020.10.023
pii: S2329-0501(20)30227-8
pmc: PMC7750493
doi:
Types de publication
Journal Article
Langues
eng
Pagination
95-108Informations de copyright
© 2020 The Author(s).
Déclaration de conflit d'intérêts
F.H., H.R., B.M.R., and B.A.C. were employees of Baxalta Innovations GmbH, a member of the Takeda group of companies, Vienna, Austria, at the time of the study. F.H., H.R. and B.A.C. are stockholders in Takeda Pharmaceutical. The remaining authors declare no competing interests.
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