Risk factors of pain, physical function, and health-related quality of life in elderly people with knee osteoarthritis: A cross-sectional study.
Aging
Aging and life course
Central sensitization
Chronic pain
Conditioned pain modulation
Diagnostics
Elderly
Knee osteoarthritis
Multiple regression analysis
Musculoskeletal system
Nervous system
Neuroscience
Rehabilitation
Systems neuroscience
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
11
05
2020
revised:
09
09
2020
accepted:
10
12
2020
entrez:
30
12
2020
pubmed:
31
12
2020
medline:
31
12
2020
Statut:
epublish
Résumé
Data on the precise mechanisms of the complex interactions of factors related to clinical impact of knee osteoarthritis (KOA) in the elderly population remain limited. To find predictors that explain pain intensity, physical function, and quality of life in elderly KOA subjects, we performed a cross-sectional analysis of the baseline data from a randomized trial. The trial included 104 subjects (aged ≥60) with KOA pain and dysfunctional endogenous pain-inhibitory system activity assessed by conditioned pain modulation (CPM). Three multiple linear regression models were performed to understand the independent predictors of Brief Pain Inventory (BPI), WOMAC function subscale (WOMACFunc), and SF-12 physical subscale (SF12-PCS). Model 1 showed that BPI pain score was predicted by low CPM response, high von-Frey light touch threshold, worse radiological severity as indexed by Kellgren-Lawrence grade (KL), high von-Frey punctate pain intensity and high levels of anxiety (adjusted R2 = 27.1%, F (6,95) = 7.27, P < 0.0001). In model 2, von-Frey light touch threshold, KL, depressive symptoms indexed by Beck Depression Inventory (BDI), level of sleepiness and pain pressure threshold were risk factors for SF12-PCS (adjusted R2 = 31.9%, F (5,96) = 10.5, P < 0.0001). Finally, model 3 showed that WOMACFunc was predicted by BDI, KL and BPI (adjusted R2 = 41%, F (3,98) = 24.42, P < 0.0001). Our data provides an interesting framework to understand the predictors of KOA pain in the elderly and highlights how its related outcomes are affected by disease-specific factors, somatosensory dysfunction and emotional factors.
Identifiants
pubmed: 33376818
doi: 10.1016/j.heliyon.2020.e05723
pii: S2405-8440(20)32566-4
pmc: PMC7758370
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e05723Informations de copyright
© 2020 The Authors.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Scand J Pain. 2017 Dec 29;4(2):111-117
pubmed: 29913902
Sleep. 2001 Feb 1;24(1):96-105
pubmed: 11204058
J Rheumatol. 1988 Dec;15(12):1833-40
pubmed: 3068365
Ann Rheum Dis. 1998 Apr;57(4):203-8
pubmed: 9709175
Health Qual Life Outcomes. 2018 Jun 18;16(1):126
pubmed: 29914521
Clin J Pain. 2020 Jan;36(1):16-24
pubmed: 31567220
Aging Clin Exp Res. 2019 Jan;31(1):19-30
pubmed: 30539541
Clin Rehabil. 2016 Sep;30(9):890-900
pubmed: 27496698
Acta Med Port. 2015 Jan-Feb;28(1):99-106
pubmed: 25817486
Clin J Pain. 2007 Jan;23(1):85-90
pubmed: 17277649
Neuropsychologia. 2009 Jan;47(1):212-7
pubmed: 18725237
Arthritis Rheum. 2013 Feb;65(2):363-72
pubmed: 22961435
J Pain Res. 2017 Nov 13;10:2657-2663
pubmed: 29180892
Emerg Med Clin North Am. 2005 May;23(2):339-48
pubmed: 15829386
Pain. 2001 Aug;93(2):107-14
pubmed: 11427321
Osteoarthritis Cartilage. 2012 Dec;20(12):1447-50
pubmed: 22897882
Psychol Med. 2008 Nov;38(11):1639-50
pubmed: 18298879
Pain. 2003 Dec;106(3):427-37
pubmed: 14659526
Clin J Pain. 2009 Sep;25(7):632-40
pubmed: 19692806
Rheumatology (Oxford). 2012 Mar;51(3):535-43
pubmed: 22120461
Physiother Theory Pract. 2019 Feb;35(2):139-147
pubmed: 29482419
Osteoarthritis Cartilage. 2015 Jul;23(7):1043-56
pubmed: 25749012
Neurosci Lett. 2012 Mar 14;512(1):12-6
pubmed: 22326385
Arthritis Rheum. 1986 Aug;29(8):1039-49
pubmed: 3741515
Curr Opin Rheumatol. 2009 Sep;21(5):501-6
pubmed: 19617836
Biol Res Nurs. 2020 Jan;22(1):57-63
pubmed: 31416344
Osteoarthritis Cartilage. 2010 Jan;18(1):24-33
pubmed: 19751691
Med Ultrason. 2016 Sep;18(3):318-25
pubmed: 27622408
Am J Psychiatry. 2005 Jun;162(6):1171-8
pubmed: 15930066
Brain. 2003 May;126(Pt 5):1079-91
pubmed: 12690048
Ann Rheum Dis. 1957 Dec;16(4):494-502
pubmed: 13498604
Open Access Rheumatol. 2016 Oct 31;8:103-113
pubmed: 27843376
Pain. 2010 Jun;149(3):573-81
pubmed: 20418016
Mod Rheumatol. 2014 Jan;24(1):166-71
pubmed: 24261774
J Orthop Res. 2019 Jan;37(1):136-142
pubmed: 30325066
Clin J Pain. 2015 Apr;31(4):315-22
pubmed: 24866856
Med Decis Making. 2001 Jul-Aug;21(4):329-34
pubmed: 11475389
BMC Musculoskelet Disord. 2008 Apr 21;9:55
pubmed: 18426591
Arch Phys Med Rehabil. 2009 Nov;90(11):1866-73
pubmed: 19887210
Pain. 2008 Aug 31;138(2):354-61
pubmed: 18289792
Eur J Pain. 2014 Nov;18(10):1367-75
pubmed: 24700605
Support Care Cancer. 2012 Feb;20(2):319-24
pubmed: 21243377
Rev Esp Cir Ortop Traumatol. 2014 Sep-Oct;58(5):283-9
pubmed: 25022212
BMC Musculoskelet Disord. 2017 Nov 13;18(1):443
pubmed: 29132347
Arthritis Rheum. 2012 Sep;64(9):2907-16
pubmed: 22421811
Rev Bras Ortop. 2014 Sep 19;49(5):520-7
pubmed: 26229855
JMIR Res Protoc. 2018 Oct 29;7(10):e11660
pubmed: 30373731
Clin Orthop Relat Res. 2008 Nov;466(11):2597-604
pubmed: 18810570
J Psychiatr Res. 1997 Sep-Oct;31(5):569-79
pubmed: 9368198
Rheumatol Int. 2005 Oct;25(8):585-90
pubmed: 15309503
Arthritis Rheum. 2012 Jun;64(6):1697-707
pubmed: 22392533
Rheumatology (Oxford). 2004 Jan;43(1):55-61
pubmed: 12923283
Physiother Res Int. 2016 Jun;21(2):77-83
pubmed: 25727096