Cell-free DNA (cfDNA) and Exosome Profiling from a Year-Long Human Spaceflight Reveals Circulating Biomarkers.

Omics Space Medicine

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
18 Dec 2020
Historique:
received: 24 08 2020
revised: 12 10 2020
accepted: 18 11 2020
entrez: 30 12 2020
pubmed: 31 12 2020
medline: 31 12 2020
Statut: epublish

Résumé

Liquid biopsies based on cell-free DNA (cfDNA) or exosomes provide a noninvasive approach to monitor human health and disease but have not been utilized for astronauts. Here, we profile cfDNA characteristics, including fragment size, cellular deconvolution, and nucleosome positioning, in an astronaut during a year-long mission on the International Space Station, compared to his identical twin on Earth and healthy donors. We observed a significant increase in the proportion of cell-free mitochondrial DNA (cf-mtDNA) inflight, and analysis of post-flight exosomes in plasma revealed a 30-fold increase in circulating exosomes and patient-specific protein cargo (including brain-derived peptides) after the year-long mission. This longitudinal analysis of astronaut cfDNA during spaceflight and the exosome profiles highlights their utility for astronaut health monitoring, as well as cf-mtDNA levels as a potential biomarker for physiological stress or immune system responses related to microgravity, radiation exposure, and the other unique environmental conditions of spaceflight.

Identifiants

pubmed: 33376973
doi: 10.1016/j.isci.2020.101844
pii: S2589-0042(20)31041-5
pmc: PMC7756145
doi:

Types de publication

Journal Article

Langues

eng

Pagination

101844

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH117406
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI125416
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES021006
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI129851
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR002385
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS076465
Pays : United States
Organisme : NIBIB NIH HHS
ID : R25 EB020393
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI151059
Pays : United States

Informations de copyright

© 2020 The Author(s).

Déclaration de conflit d'intérêts

S.M.B. is a cofounder and Scientific Advisory Board member of KromaTiD, Inc. C.E.M. is a cofounder and board member for Biotia, Inc. and Onegevity Health, Inc., as well as an advisor or grantee for Abbvie, Inc., ArcBio, Daiichi Sankyo, DNA Genotek, Karius, Inc., and Whole Biome, Inc. D.B. is a cofounder of Poppy Health, Inc. and Analogs Llc.

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Auteurs

Daniela Bezdan (D)

Department of Physiology and Biophysics, Weill Cornell Medicine, 1305 York Avenue, Y13-05, New York, NY 10021, USA.
Institute of Medical Virology and Epidemiology of Viral Diseases, University Hospital, Tubingen, Germany.

Kirill Grigorev (K)

Department of Physiology and Biophysics, Weill Cornell Medicine, 1305 York Avenue, Y13-05, New York, NY 10021, USA.

Cem Meydan (C)

Department of Physiology and Biophysics, Weill Cornell Medicine, 1305 York Avenue, Y13-05, New York, NY 10021, USA.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA.

Fanny A Pelissier Vatter (FA)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medical College, New York, NY, USA.

Michele Cioffi (M)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medical College, New York, NY, USA.

Varsha Rao (V)

Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.

Matthew MacKay (M)

Department of Physiology and Biophysics, Weill Cornell Medicine, 1305 York Avenue, Y13-05, New York, NY 10021, USA.

Kiichi Nakahira (K)

Nara Medical University, Kashihara, Nara, Japan.

Philip Burnham (P)

Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

Ebrahim Afshinnekoo (E)

Department of Physiology and Biophysics, Weill Cornell Medicine, 1305 York Avenue, Y13-05, New York, NY 10021, USA.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA.

Craig Westover (C)

Department of Physiology and Biophysics, Weill Cornell Medicine, 1305 York Avenue, Y13-05, New York, NY 10021, USA.

Daniel Butler (D)

Department of Physiology and Biophysics, Weill Cornell Medicine, 1305 York Avenue, Y13-05, New York, NY 10021, USA.

Chris Mozsary (C)

Department of Physiology and Biophysics, Weill Cornell Medicine, 1305 York Avenue, Y13-05, New York, NY 10021, USA.

Timothy Donahoe (T)

Department of Physiology and Biophysics, Weill Cornell Medicine, 1305 York Avenue, Y13-05, New York, NY 10021, USA.

Jonathan Foox (J)

Department of Physiology and Biophysics, Weill Cornell Medicine, 1305 York Avenue, Y13-05, New York, NY 10021, USA.

Tejaswini Mishra (T)

Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.

Serena Lucotti (S)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medical College, New York, NY, USA.

Brinda K Rana (BK)

Department of Psychiatry University of California, San Diego, La Jolla, CA, USA.

Ari M Melnick (AM)

Department of Medicine, Weill Cornell Medicine, New York, NY, USA.

Haiying Zhang (H)

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Irina Matei (I)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medical College, New York, NY, USA.

David Kelsen (D)

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Kenneth Yu (K)

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

David C Lyden (DC)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medical College, New York, NY, USA.

Lynn Taylor (L)

Department of Environmental & Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA.

Susan M Bailey (SM)

Department of Environmental & Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA.

Michael P Snyder (MP)

Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.

Francine E Garrett-Bakelman (FE)

Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA.
Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, USA.
University of Virginia Cancer Center, Charlottesville, VA, USA.

Stephan Ossowski (S)

Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.

Iwijn De Vlaminck (I)

Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.

Christopher E Mason (CE)

Department of Physiology and Biophysics, Weill Cornell Medicine, 1305 York Avenue, Y13-05, New York, NY 10021, USA.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA.
The Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.

Classifications MeSH