Tomographic and aberrometric assessment of first-time diagnosed paediatric keratoconus based on age ranges: a multicentre study.
Paediatric keratoconus
anterior segment disorders
corneal disorders
keratoconus
keratoconus age
Journal
Acta ophthalmologica
ISSN: 1755-3768
Titre abrégé: Acta Ophthalmol
Pays: England
ID NLM: 101468102
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
revised:
09
11
2020
received:
14
05
2020
accepted:
15
11
2020
pubmed:
31
12
2020
medline:
6
1
2022
entrez:
30
12
2020
Statut:
ppublish
Résumé
To describe paediatric keratoconus (KC) patients by tomographic and aberrometric characteristics at first diagnosis, in a multicentre study. We included 278 eyes from 139 paediatric patients, with a first tomographic diagnosis (Pentacam 278 eyes were screened, and 230 eyes were diagnosed with paediatric KC. Mean age was 15.48 ± 2.33 (6 to 18) years. We found differences in terms of TKC (2.08 ± 0.89 and 2.38 ± 0.82, p < 0.05) and spherical aberration (-0.71 ± 0.97 and -1.07 ± 1.36, p < 0.05) among the 14 years old or under and above 14 years old groups, respectively. Overall, female paediatric KC patients presented a more severe TKC, Belin Ambrosio Display, maximum keratometry, asphericity and primary and secondary coma aberrations compared to male KC patients. We observed a correlation between CDVA and asphericity (r = 0.71, p < 0.01), as well as between CDVA and spherical aberration (r = 0.69, p < 0.01). Our findings revealed that the debut of KC is usually in a moderate to advanced stage in the paediatric population at first diagnosis, particularly in female patients. Corneal tomography should be systematically performed in children with recent onset of corneal astigmatism.
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
e929-e936Informations de copyright
© 2020 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.
Références
Al Suhaibani AH, Al-Rajhi AA, Al-Motowa S, Wagoner MD & Al-Rajhi AA (2007): Inverse relationship between age and severity and sequelae of acute corneal hydrops associated with keratoconus. Br J Ophthalmol 91: 984-985.
Alió JL, Piñero DP, Alesón A et al. (2011): Keratoconus-integrated characterization considering anterior corneal aberrations, internal astigmatism, and corneal biomechanics. J Cataract Refract Surg 37: 552-568.
Alió JL & Shabayek MH (2006): Corneal higher order aberrations: a method to grade keratoconus. J Refract Surg 22: 539-545.
Assiri AA, Yousuf BI, Quantock AJ, Murphy PJ & Assiri AA (2005): Incidence and severity of keratoconus in Asir province, Saudi Arabia. Br J Ophthalmol 89: 1403-1406.
Barr JT, Wilson BS, Gordon MO, Rah MJ, Riley C, Kollbaum PS & Zadnik K (2006): Estimation of the incidence and factors predictive of corneal scarring in the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) study. Cornea 25: 16-25.
Bühren J, Kühne C & Kohnen T (2007): Defining subclinical keratoconus using corneal first-surface higher-order aberrations. Am J Ophthalmol 143: 381-9.
Bunce C, Patel KV, Xing W, Freemantle N & Doré C & Ophthalmic Statistics Group (2014): Ophthalmic statistics note 1: unit of analysis. Br J Ophthalmol 98: 408-12.
Chatzis N & Hafezi F (2012): Progression of keratoconus and efficacy of corneal collagen cross-linking in children and adolescents. J Refract Surg 28: 753-758.
Dana MR, Putz JL, Viana MAG, Sugar J & McMahon TT (1992): Contact lens failure in keratoconus management. Ophthalmology 99: 1187-1192.
El-Khoury S, Abdelmassih Y, Hamade A, Slim E, Cherfan CG, Chelala E, Bleik J & Jarade EF (2016): Pediatric keratoconus in a tertiary referral center: Incidence, presentation, risk factors, and treatment. J Refract Surg 32: 534-541.
Ertan A & Muftuoglu O (2008): Keratoconus clinical findings according to different age and gender groups. Cornea 27: 1109-1113.
Fink BA, Wagner H, Steger-May K, Rosenstiel C, Roediger T, Mcmahon TT, Gordon MO & Zadnik K (2005): Differences in keratoconus as a function of gender. Am J Ophthalmol 140: 459-68.
Galvis V, Sherwin T, Tello A, Merayo J, Barrera R & Acera A (2015): Keratoconus: an inflammatory disorder? Eye 29: 843-859.
Gobbe M & Guillon M (2005): Corneal wavefront aberration measurements to detect keratoconus patients. Contact Lens Anterior Eye 28: 57-66.
Goebels S, Eppig T, Wagenpfeil S, Cayless A, Seitz B & Langenbucher A (2015): Staging of keratoconus indices regarding tomography, topography, and biomechanical measurements. Am J Ophthalmol 159: 733-738.
Golan O, Piccinini AL, Hwang ES, De Oca Gonzalez IM, Krauthammer M, Khandelwal SS, Smadja D & Randleman JB (2019): Distinguishing highly asymmetric keratoconus eyes using dual Scheimpflug/Placido analysis. Am J Ophthalmol 201: 46-53.
Gomes JAP, Tan D, Rapuano CJ et al. (2015): Global consensus on keratoconus and ectatic diseases. Cornea 34: 359-369.
Hashemi H, Heydarian S, Hooshmand E et al. (2020): The prevalence and risk factors for keratoconus: a systematic review and meta-analysis. Cornea 39: 263-270.
Hwang ES, Perez-Straziota CE, Kim SW, Santhiago MR & Randleman JB (2018): Distinguishing highly asymmetric keratoconus eyes using combined Scheimpflug and spectral-domain OCT analysis. Ophthalmology 125: 1862-1871.
Kennedy RH, Bourne WM & Dyer JA (1986): A 48-year clinical and epidemiologic study of keratoconus. Am J Ophthalmol 101: 267-273.
Lee HK, Jung EH & Cho BJ (2020): Epidemiological association between systemic diseases and keratoconus in a Korean population: A 10-Year Nationwide Cohort Study. Cornea 39: 348-353.
Léoni-Mesplié S, Mortemousque B, Touboul D, Malet F, Praud D, Mesplié N & Colin J (2012): Scalability and severity of keratoconus in children. Am J Ophthalmol 154: 56-62.
Li X, Rabinowitz YS, Rasheed K & Yang H (2004): Longitudinal study of the normal eyes in unilateral keratoconus patients. Ophthalmology 111: 440-446.
Loh I-P & Sherwin T. (2020): Is Keratoconus an Inflammatory Disease? The Implication of Inflammatory Pathways. Ocul Immunol Inflammat 1-10. doi: 10.1080/09273948.2020.1780271. Online ahead of print.
Moran S, Gomez L, Zuber K & Gatinel D (2020): A case-control study of keratoconus risk factors. Cornea 39: 697-701.
Moshirfar M, Heiland MB, Rosen DB, Ronquillo YC & Hoopes PC (2019): Keratoconus screening in elementary school children. Ophthalmol Ther 8: 367-371.
Mukhtar S & Ambati BK (2018): Pediatric keratoconus: a review of the literature. Int Ophthalmol 38: 2257-2266.
Naderan M, Rajabi MT, Zarrinbakhsh P & Farjadnia M (2017): Is keratoconus more severe in pediatric population? Int Ophthalmol 37: 1169-1173.
Naderan M, Shoar S, Kamaleddin MA, Rajabi MT, Naderan M & Khodadadi M (2015): Keratoconus clinical findings according to different classifications. Cornea 34: 1005-1011.
Ozer MD, Batur M, Mesen S, Tekin S & Seven E (2019): Long-term results of accelerated corneal cross-linking in adolescent patients with keratoconus. Cornea 38: 992-997.
Padmanabhan P, Rachapalle Reddi S, Rajagopal R et al. (2017): Corneal collagen cross-linking for keratoconus in pediatric patients - long-term results. Cornea 36: 138-143.
Pahuja NK, Shetty R, Sinha Roy A, Thakkar MM, Jayadev C, Nuijts RM & Nagaraja H (2017): Laser vision correction with Q factor modification for keratoconus management. Curr Eye Res 42: 542-548.
Papaliʼi-Curtin AT, Cox R, Ma T, Woods L, Covello A & Hall RC (2019): Keratoconus prevalence among high school students in New Zealand. Cornea 38: 1382-1389.
Piñero DP, Alió JL, Alesón A, Escaf M & Miranda M (2009): Pentacam posterior and anterior corneal aberrations in normal and keratoconic eyes. Clin Exp Optom 92: 297-303.
Pouliquen Y, Forman MR & Giraud JP (1981): Vitesse D’Evolution Du keratocone. Etude Des Relations Entre L’Age De Decouverte Et L’Age Auquel Il Est Opere. J Fr Ophtalmol 4: 219-221.
Saad A & Gatinel D (2010): Topographic and tomographic properties of forme fruste keratoconus corneas. Investig Ophthalmol Vis Sci 51: 5546-5555.
Sabti S, Tappeiner C & Frueh BE (2015): Corneal cross-linking in a 4-year-old child with keratoconus and down syndrome. Cornea 34: 1157-1160.
Saini JS, Saroha V, Singh P, Sukhija JS & Jain AK (2004): Keratoconus in Asian eyes at a tertiary eye care facility. Clin Exp Optom 87: 97-101.
de Sanctis U, Loiacono C, Richiardi L, Turco D, Mutani B & Grignolo FM (2008): Sensitivity and specificity of posterior corneal elevation measured by pentacam in discriminating keratoconus/subclinical keratoconus. Ophthalmology 115: 1534-1539.
Schlegel Z, Hoang-Xuan T & Gatinel D (2008): Comparison of and correlation between anterior and posterior corneal elevation maps in normal eyes and keratoconus-suspect eyes. J Cataract Refract Surg 34: 789-795.
Smadja D, Touboul D, Cohen A, Doveh E, Santhiago MR, Mello GR, Krueger RR & Colin J (2013): Detection of subclinical keratoconus using an automated decision tree classification. Am J Ophthalmol 156: 237-246.
Uçakhan ÖÖ, Çetinkor V, Özkan M & Kanpolat A (2011): Evaluation of Scheimpflug imaging parameters in subclinical keratoconus, keratoconus, and normal eyes. J Cataract Refract Surg 37: 1116-1124.
Zadnik K, Barr JT, Gordon MO & Edrington TB (1996): Biomicroscopic signs and disease severity in keratoconus. Cornea 15: 139-146.