Site-Directed Mutations of Calcium-Binding Sites Contribute to Reducing the Immunoreactivity of the EF-Hand Sarcoplasmic Calcium-Binding Protein in

Amino Acid Sequence Animals Arthropod Proteins / chemistry Basophils / immunology Brachyura / chemistry Calcium-Binding Proteins / chemistry Circular Dichroism Epitopes / chemistry Humans Immunoglobulin E / immunology Mutagenesis, Site-Directed Sequence Alignment Shellfish Hypersensitivity / immunology
calcium-binding sites conformational epitope food allergy sarcoplasmic calcium-binding protein site-directed mutagenesis

Journal

Journal of agricultural and food chemistry
ISSN: 1520-5118
Titre abrégé: J Agric Food Chem
Pays: United States
ID NLM: 0374755

Informations de publication

Date de publication:
13 Jan 2021
Historique:
pubmed: 31 12 2020
medline: 13 4 2021
entrez: 30 12 2020
Statut: ppublish

Résumé

In order to reduce the immunoreactivity of sarcoplasmic calcium-binding protein (SCP), site-directed mutations were used to replace key amino acids in the conformational epitopes and calcium-binding sites. The mutant SCPs (mSCPs) were expressed in

Identifiants

DOI: 10.1021/acs.jafc.0c05733 PMID: 33377774
pubmed: 33377774
doi: 10.1021/acs.jafc.0c05733
doi:

Substances chimiques

Arthropod Proteins 0
Calcium-Binding Proteins 0
Epitopes 0
Immunoglobulin E 37341-29-0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

428-436

Auteurs

Yi-Yu Chen (YY)

College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen, Fujian 361021, China.

Meng-Si Li (MS)

College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen, Fujian 361021, China.

Xiao Yun (X)

College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen, Fujian 361021, China.

Fei Xia (F)

College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen, Fujian 361021, China.

Meng-Jun Hu (MJ)

College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen, Fujian 361021, China.

Tengchuan Jin (T)

Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science & Technology of China, Hefei, Anhui 230026, China.
ORCID: 0000-0002-1395-188X

Min-Jie Cao (MJ)

College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen, Fujian 361021, China.

Dong Lai (D)

The Second Affiliated Hospital of Xiamen Medical College, Xiamen, Fujian 361021, China.

Guixia Chen (G)

Women and Children's Hospital Affiliated to Xiamen University, Xiamen, Fujian 361003, China.

Guang-Ming Liu (GM)

College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen, Fujian 361021, China.
ORCID: 0000-0002-8689-0504

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › Site-Directed Mutations of Calcium-Binding...
questionsmedicales.fr › Eucaryotes › Animaux › Site-Directed Mutations of Calcium-Binding...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'arthropode › Site-Directed Mutations of Calcium-Binding...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Granulocytes › Granulocytes basophiles › Site-Directed Mutations of Calcium-Binding...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Crustacea › Decapoda (crustacea) › Brachyura › Site-Directed Mutations of Calcium-Binding...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Protéines de liaison au calcium › Site-Directed Mutations of Calcium-Binding...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Dichroïsme circulaire › Site-Directed Mutations of Calcium-Binding...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Épitopes › Site-Directed Mutations of Calcium-Binding...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Site-Directed Mutations of Calcium-Binding...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline E › Site-Directed Mutations of Calcium-Binding...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Génie génétique › Ingénierie des protéines › Mutagenèse dirigée › Site-Directed Mutations of Calcium-Binding...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Alignement de séquences › Site-Directed Mutations of Calcium-Binding...
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Hypersensibilité alimentaire › Hypersensibilité aux fruits de mer › Site-Directed Mutations of Calcium-Binding...