An open study of valproate in subfertile men with epilepsy.
Adult
Anticonvulsants
/ adverse effects
Drug Substitution
Epilepsy
/ drug therapy
Female
Greece
Humans
Infertility, Male
/ chemically induced
Lamotrigine
/ therapeutic use
Levetiracetam
/ therapeutic use
Male
Pregnancy
Pregnancy Rate
Prospective Studies
Sperm Count
Sperm Motility
/ drug effects
Spermatozoa
/ drug effects
Valproic Acid
/ adverse effects
antiepileptic drugs
epilepsy
fertility
infertility
males
semen
sperm
valproic acid
Journal
Acta neurologica Scandinavica
ISSN: 1600-0404
Titre abrégé: Acta Neurol Scand
Pays: Denmark
ID NLM: 0370336
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
08
05
2020
revised:
17
06
2020
accepted:
28
06
2020
entrez:
30
12
2020
pubmed:
31
12
2020
medline:
2
3
2021
Statut:
ppublish
Résumé
The aim of the study was to assess whether, male patients with epilepsy, switching from valproic acid (VPA) to levetiracetam (LEV) or lamotrigine (LMG) critically improves sperm counts and parameters, increasing chance of patients' female partners to spontaneously conceive. This is an observational prospective study recruiting all consecutive infertile male patients with epilepsy followed up at the outpatient Epilepsy Clinic of University Hospital of Ioannina, Northwest Greece. Infertile couples were referred to the Laboratory of Assisted Reproduction and Treatment of the University Hospital of Ioannina to conduct semen analysis. The first sample was collected while the patients were receiving VPA, and the second semen sample was collected after the patients were switched to LEV or LMG. Seventeen infertile male patients were recruited in the study. Nine patients were switched to LEV, and eight patients were switched to LMG. The mean sperm count increased after VPA withdraw P = .06. Motility was improved with an increase of total motility and non-progressive motility (P = .02 and P = .03, accordingly), whether sperm defects were decreased, mainly head defects (P = .03). Differences between patients switched to LEV or LMG were minimal and showed no significant findings. Spontaneous pregnancies were reported in three of the patients' partners, without any other clinical intervention offered to the couple. Switching from valproic acid to levetiracetam or lamotrigine improved sperm counts and other sperm parameters in subfertile male patients and increased the chance of spontaneously conceiving in subfertile couples.
Substances chimiques
Anticonvulsants
0
Levetiracetam
44YRR34555
Valproic Acid
614OI1Z5WI
Lamotrigine
U3H27498KS
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
317-322Informations de copyright
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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