KLF10 Deficiency in CD4

Adipose Tissue / metabolism Animals Cells, Cultured Early Growth Response Transcription Factors / genetics Fatty Liver / genetics Female Gene Expression Regulation Genetic Predisposition to Disease Humans Inflammation / metabolism Insulin Resistance Kruppel-Like Transcription Factors / genetics Liver / metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Mitochondria / metabolism Obesity / genetics Phosphatidylinositol 3-Kinase / metabolism Signal Transduction T-Lymphocytes, Regulatory / metabolism Transforming Growth Factor beta3 / metabolism
CD4(+) T cell KLF10 PI3K-Akt-mTOR pathway Treg glycolysis metabolic disorders mitochondria obesity oxidative phosphorylation

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
29 12 2020
Historique:
received: 16 04 2019
revised: 15 11 2019
accepted: 02 12 2020
entrez: 30 12 2020
pubmed: 31 12 2020
medline: 14 10 2021
Statut: ppublish

Résumé

CD4

Identifiants

DOI: 10.1016/j.celrep.2020.108550 PMID: 33378664 PMC: PMC7816773
pubmed: 33378664
pii: S2211-1247(20)31539-4
doi: 10.1016/j.celrep.2020.108550
pmc: PMC7816773
mid: NIHMS1658623
pii:
doi:

Substances chimiques

Early Growth Response Transcription Factors 0
KLF10 protein, mouse 0
Kruppel-Like Transcription Factors 0
Transforming Growth Factor beta3 0
Phosphatidylinositol 3-Kinase EC 2.7.1.137

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

108550

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL153356
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL148355
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK034854
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL115141
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL148207
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL134849
Pays : United States

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors declare no competing interests.

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Auteurs

Akm Khyrul Wara (AK)

Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Shijia Wang (S)

Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Chun Wu (C)

Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Fang Fang (F)

Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Hematology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Stefan Haemmig (S)

Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Brittany N Weber (BN)

Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Ceren O Aydogan (CO)

Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Cerrahpasa District, Kocamustafapasa Street, Number 34/E, Fatih, Istanbul, Turkey.

Yevgenia Tesmenitsky (Y)

Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Hassan Aliakbarian (H)

Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

John R Hawse (JR)

Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA.

Malayannan Subramaniam (M)

Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA.

Lei Zhao (L)

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Peter T Sage (PT)

Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Ali Tavakkoli (A)

Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Cerrahpasa District, Kocamustafapasa Street, Number 34/E, Fatih, Istanbul, Turkey.

Amanda Garza (A)

Department of Medicine, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Boston, MA 02115, USA.

Lydia Lynch (L)

Department of Medicine, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Boston, MA 02115, USA.

Alexander S Banks (AS)

Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

Mark W Feinberg (MW)

Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: mfeinberg@bwh.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › KLF10 Deficiency in CD4
questionsmedicales.fr › Eucaryotes › Animaux › KLF10 Deficiency in CD4
questionsmedicales.fr › Cellules › Cellules cultivées › KLF10 Deficiency in CD4
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription EGR › KLF10 Deficiency in CD4
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Stéatose hépatique › KLF10 Deficiency in CD4
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › KLF10 Deficiency in CD4
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › KLF10 Deficiency in CD4
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › KLF10 Deficiency in CD4
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › KLF10 Deficiency in CD4
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Insulinorésistance › KLF10 Deficiency in CD4
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription Krüppel-like › KLF10 Deficiency in CD4
questionsmedicales.fr › Système digestif › Foie › KLF10 Deficiency in CD4
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › KLF10 Deficiency in CD4
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › KLF10 Deficiency in CD4
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › KLF10 Deficiency in CD4
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › KLF10 Deficiency in CD4
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › KLF10 Deficiency in CD4
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphatidylinositol 3-kinases › Phosphatidylinositol 3-kinase › KLF10 Deficiency in CD4
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › KLF10 Deficiency in CD4
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › KLF10 Deficiency in CD4
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Facteur de croissance transformant bêta › Facteur de croissance transformant bêta-3 › KLF10 Deficiency in CD4