Comparison of Four SARS-CoV-2 Neutralization Assays.
SARS-CoV-2
neutralization assay
neutralizing antibodies
pseudotype virus
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
28 Dec 2020
28 Dec 2020
Historique:
received:
27
11
2020
revised:
18
12
2020
accepted:
20
12
2020
entrez:
31
12
2020
pubmed:
1
1
2021
medline:
1
1
2021
Statut:
epublish
Résumé
Neutralizing antibodies are a major correlate of protection for many viruses including the novel coronavirus SARS-CoV-2. Thus, vaccine candidates should potently induce neutralizing antibodies to render effective protection from infection. A variety of in vitro assays for the detection of SARS-CoV-2 neutralizing antibodies has been described. However, validation of the different assays against each other is important to allow comparison of different studies. Here, we compared four different SARS-CoV-2 neutralization assays using the same set of patient samples. Two assays used replication competent SARS-CoV-2, a focus forming assay and a TCID
Identifiants
pubmed: 33379160
pii: vaccines9010013
doi: 10.3390/vaccines9010013
pmc: PMC7824240
pii:
doi:
Types de publication
Journal Article
Langues
eng
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