Nicotine Changes Airway Epithelial Phenotype and May Increase the SARS-COV-2 Infection Severity.

Angiotensin-Converting Enzyme 2 / metabolism COVID-19 / pathology Cell Line Cell Movement / drug effects Cell Proliferation / drug effects Cell Survival / drug effects Epithelial Cells / drug effects Humans Nicotine / adverse effects Receptors, Nicotinic / metabolism Respiratory System / drug effects SARS-CoV-2 / pathogenicity Severity of Illness Index Signal Transduction / drug effects Smoking / adverse effects alpha7 Nicotinic Acetylcholine Receptor / metabolism
EMT SARS-CoV-2 cell proliferation mitochondrial dysfunction nAChR nicotine

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
28 Dec 2020
Historique:
received: 04 11 2020
revised: 17 12 2020
accepted: 24 12 2020
entrez: 31 12 2020
pubmed: 1 1 2021
medline: 14 1 2021
Statut: epublish

Résumé

(1) Background: Nicotine is implicated in the SARS-COV-2 infection through activation of the α7-nAChR and over-expression of ACE2. Our objective was to clarify the role of nicotine in SARS-CoV-2 infection exploring its molecular and cellular activity. (2) Methods: HBEpC or si-mRNA-α7-HBEpC were treated for 1 h, 48 h or continuously with 10

Identifiants

DOI: 10.3390/molecules26010101 PMID: 33379366 PMC: PMC7794754
pubmed: 33379366
pii: molecules26010101
doi: 10.3390/molecules26010101
pmc: PMC7794754
pii:
doi:

Substances chimiques

Receptors, Nicotinic 0
alpha7 Nicotinic Acetylcholine Receptor 0
Nicotine 6M3C89ZY6R
Angiotensin-Converting Enzyme 2 EC 3.4.17.23

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Références

Biol Cell. 2005 Feb;97(2):147-72
pubmed: 15656780
Toxicon. 2004 May;43(6):619-32
pubmed: 15109883
J Mol Biol. 2017 Dec 8;429(24):3875-3892
pubmed: 29056462
J Cell Commun Signal. 2020 Dec;14(4):467-468
pubmed: 32815099
Curr Neuropharmacol. 2018;16(4):338-349
pubmed: 28901280
Biochem Pharmacol. 2009 Oct 1;78(7):732-43
pubmed: 19523455
PeerJ. 2020 Jun 5;8:e9369
pubmed: 32547891
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
Acta Biomed. 2020 Aug 27;91(3):e2020062
pubmed: 32921714
Int J Mol Sci. 2020 Aug 13;21(16):
pubmed: 32823591
Lancet. 2020 Feb 22;395(10224):565-574
pubmed: 32007145
Mutat Res. 2008 Sep-Oct;659(3):221-31
pubmed: 18495523
Lancet Rheumatol. 2020 Dec;2(12):e754-e763
pubmed: 33015645
Cell. 2012 Dec 7;151(6):1168-78
pubmed: 23217704
Crit Rev Toxicol. 2012 Jan;42(1):68-89
pubmed: 22050423
Methods Mol Biol. 2021;2206:1-13
pubmed: 32754806
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Rev Med Virol. 2011 May;21(3):181-200
pubmed: 21538666
Am J Physiol Lung Cell Mol Physiol. 2016 Feb 1;310(3):L232-9
pubmed: 26608528
J Vasc Res. 2012;49(5):390-404
pubmed: 22739226
Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1245-52
pubmed: 24379363
Mol Cancer Res. 2014 Jan;12(1):14-23
pubmed: 24398389
Nat Commun. 2019 Sep 13;10(1):4200
pubmed: 31519880
Oncol Rep. 2017 Dec;38(6):3309-3318
pubmed: 29039603
Pharmacol Ther. 2013 Jan;137(1):22-54
pubmed: 22925690
Pharmacol Res. 2020 Aug;158:104850
pubmed: 32360580
Arch Toxicol. 2014 Jan;88(1):5-7
pubmed: 24091634
J Biomed Sci. 2016 Jan 22;23:14
pubmed: 26801988
Int Immunopharmacol. 2020 Feb 24;82:106303
pubmed: 32106059
Acta Biomed. 2020 May 11;91(2):106-112
pubmed: 32420934
Br J Cancer. 2020 Mar;122(6):904-911
pubmed: 32001831
Environ Toxicol. 2019 Jan;34(1):73-82
pubmed: 30259641
J Pharmacol Exp Ther. 2020 Dec;375(3):498-509
pubmed: 33033170
PLoS One. 2020 May 11;15(5):e0233147
pubmed: 32392262
Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4099-104
pubmed: 23431157
Pulm Pharmacol Ther. 2007;20(6):629-41
pubmed: 17015027
Front Immunol. 2020 Jun 26;11:1626
pubmed: 32714336
N Engl J Med. 2020 Jul 9;383(2):120-128
pubmed: 32437596
Cell. 2020 Apr 16;181(2):281-292.e6
pubmed: 32155444
Nat Rev Cancer. 2009 Mar;9(3):195-205
pubmed: 19194381
Nicotine Tob Res. 2020 Aug 24;22(9):1650-1652
pubmed: 32242236
Cold Spring Harb Perspect Biol. 2017 Sep 1;9(9):
pubmed: 28864602
PLoS One. 2019 May 31;14(5):e0217339
pubmed: 31150435
PLoS Pathog. 2006 Dec;2(12):e132
pubmed: 17173481
Drug Discov Today. 2009 Sep;14(17-18):822-36
pubmed: 19616116
Cancers (Basel). 2018 Jun 04;10(6):
pubmed: 29866997
FEBS J. 2020 Sep;287(17):3612-3632
pubmed: 32500928
Front Cell Dev Biol. 2020 Sep 16;8:559841
pubmed: 33042994
BMJ Open Respir Res. 2020 Jul;7(1):
pubmed: 32624493
Cell Mol Neurobiol. 2005 Jun;25(3-4):513-52
pubmed: 16075378
Cell. 2020 Jul 23;182(2):429-446.e14
pubmed: 32526206
Nicotine Tob Res. 2020 Aug 24;22(9):1646-1649
pubmed: 32609839
Perspect Biol Med. 2011 Autumn;54(4):557-77
pubmed: 22019540
Semin Cancer Biol. 2008 Jun;18(3):211-7
pubmed: 18262434
Addiction. 2021 May;116(5):1186-1195
pubmed: 32918300
Gene Rep. 2020 Sep;20:100765
pubmed: 32835132
Exp Cell Res. 1965 Mar;37:614-36
pubmed: 14315085
FEBS J. 2020 Sep;287(17):3651-3655
pubmed: 32189428
Cold Spring Harb Perspect Med. 2021 May 3;11(5):
pubmed: 32341069
Int J Oncol. 2000 Mar;16(3):513-8
pubmed: 10675483
Psychopharmacology (Berl). 2007 Feb;190(3):269-319
pubmed: 16896961
Int J Cancer. 2009 Jan 1;124(1):36-45
pubmed: 18844224
Redox Biol. 2020 Jun;33:101443
pubmed: 32037306
Res Commun Mol Pathol Pharmacol. 1997 Sep;97(3):243-62
pubmed: 9387186
Am J Respir Cell Mol Biol. 2007 Dec;37(6):681-90
pubmed: 17600315
Cell. 2020 Aug 6;182(3):685-712.e19
pubmed: 32645325
Eur Respir J. 2020 Jun 4;55(6):
pubmed: 32350104
Mol Cancer. 2010 Aug 20;9:220
pubmed: 20727180
Eur Respir J. 2020 Aug 13;56(2):
pubmed: 32554535
Lancet Respir Med. 2020 Jun;8(6):e50-e51
pubmed: 32411576
Philos Trans R Soc Lond B Biol Sci. 2018 Jun 19;373(1749):
pubmed: 29735728
FASEB J. 2004 Sep;18(12):1436-8
pubmed: 15247149
Am J Respir Crit Care Med. 2020 Jun 15;201(12):1557-1559
pubmed: 32329629
Int J Mol Sci. 2020 Jun 30;21(13):
pubmed: 32630064
Eur Respir J. 2020 Aug 13;56(2):
pubmed: 32817205
Nature. 2018 Mar 8;555(7695):251-255
pubmed: 29489752
Eur Respir J. 2021 Mar 4;57(3):
pubmed: 32732325
J Adolesc Health. 2020 Oct;67(4):519-523
pubmed: 32798097
J Intern Med. 2020 Feb;287(2):120-133
pubmed: 31710126
Pathol Res Pract. 2008;204(12):891-8
pubmed: 18667281
Cell Biochem Biophys. 2012 Apr;62(3):421-31
pubmed: 22095388
J Bioenerg Biomembr. 2019 Aug;51(4):259-276
pubmed: 31197632
Cell Death Differ. 2020 Dec;27(12):3209-3225
pubmed: 33037393
Neurochem Int. 2019 May;125:117-126
pubmed: 30779928
Toxicol Rep. 2020 Apr 30;7:658-663
pubmed: 32355638
Eur Respir J. 2020 Jun 4;55(6):
pubmed: 32341101
Oncol Rep. 2018 Oct;40(4):2097-2104
pubmed: 30015910
PLoS Biol. 2004 Aug;2(8):E217
pubmed: 15314646
Front Microbiol. 2021 Feb 26;12:638231
pubmed: 33717032
Front Genet. 2021 Mar 16;12:599261
pubmed: 33796130
Carcinogenesis. 2011 Sep;32(9):1388-95
pubmed: 21586512
Science. 2020 Mar 27;367(6485):1444-1448
pubmed: 32132184
EMBO J. 2020 May 18;39(10):e105114
pubmed: 32246845
J Med Virol. 2020 Oct;92(10):1915-1921
pubmed: 32293753
C R Biol. 2020 Jun 05;343(1):33-39
pubmed: 32720486
Intern Emerg Med. 2020 Aug;15(5):845-852
pubmed: 32385628
Life Sci. 2003 Mar 28;72(18-19):2055-61
pubmed: 12628456
Respir Res. 2020 Jul 14;21(1):182
pubmed: 32664949
Am J Physiol Lung Cell Mol Physiol. 2013 Feb 15;304(4):L199-209
pubmed: 23204070
Int Immunopharmacol. 2020 Apr;81:106289
pubmed: 32113128
Handb Exp Pharmacol. 2012;(208):469-91
pubmed: 22222711
J Renin Angiotensin Aldosterone Syst. 2020 Apr-Jun;21(2):1470320320928872
pubmed: 32490715
Nature. 2003 Jan 23;421(6921):384-8
pubmed: 12508119
Jpn J Pharmacol. 2001 Jan;85(1):2-10
pubmed: 11243568
Curr Drug Targets. 2012 May;13(5):587-93
pubmed: 22300024
Mol Pharmacol. 2020 Aug;98(2):168-180
pubmed: 32474444
Lancet Respir Med. 2020 Jul;8(7):664-665
pubmed: 32464099
Heliyon. 2017 Dec 01;3(11):e00469
pubmed: 29264422
Cell Mol Neurobiol. 2018 Oct;38(7):1335-1348
pubmed: 30008143
J Autoimmun. 2020 Aug;112:102463
pubmed: 32303424
Curr Opin Virol. 2019 Apr;35:57-62
pubmed: 31125806
Tob Induc Dis. 2020 Mar 20;18:20
pubmed: 32206052
Virology. 2007 Oct 25;367(2):367-74
pubmed: 17631932
Nature. 2020 Jul;583(7816):469-472
pubmed: 32408336
J Neurochem. 2017 Aug;142 Suppl 2:144-150
pubmed: 28072454
Am J Respir Cell Mol Biol. 2009 Feb;40(2):135-46
pubmed: 18676776
Respir Res. 2020 Jun 18;21(1):154
pubmed: 32552811
Nature. 2020 Jul;583(7816):459-468
pubmed: 32353859
J Virol. 2006 Jan;80(2):785-93
pubmed: 16378980
J Virol. 2020 Jun 16;94(13):
pubmed: 32295925
Int Immunopharmacol. 2015 Nov;29(1):36-44
pubmed: 26071223
Science. 2020 Sep 4;369(6508):1249-1255
pubmed: 32680882
Front Med (Lausanne). 2022 Jan 05;8:668995
pubmed: 35071251
Cell Syst. 2016 Sep 28;3(3):252-263.e8
pubmed: 27667364

Auteurs

Leonardo Lupacchini (L)

Molecular and Cellular Neurobiology, IRCSS San Raffaele Pisana, Via di Val Cannuta, 247, I-00166 Rome, Italy.

Fabrizio Maggi (F)

Department of Medicine and Surgery, and Laboratory of Clinical Microbiology, University of Insubria, ASST dei Sette Laghi, viale Luigi Borri 57, I-21100 Varese, Italy.
ORCID: 0000-0001-7489-5271

Carlo Tomino (C)

Scientific Direction, IRCSS San Raffaele Pisana, Via di Val Cannuta, 247, I-00166 Rome, Italy.

Chiara De Dominicis (C)

Molecular and Cellular Neurobiology, IRCSS San Raffaele Pisana, Via di Val Cannuta, 247, I-00166 Rome, Italy.

Cristiana Mollinari (C)

Institute of Translational Pharmacology, National Research Council, Via Fosso del Cavaliere 100, 00133 Rome, Italy.
Department of Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299, I-00161 Rome, Italy.

Massimo Fini (M)

Scientific Direction, IRCSS San Raffaele Pisana, Via di Val Cannuta, 247, I-00166 Rome, Italy.

Stefano Bonassi (S)

Clinical and Molecular Epidemiology, IRCSS San Raffaele Pisana, Via di Val Cannuta, 247, I-00166 Rome, Italy.
Department of Human Sciences and Quality of Life Promotion San Raffaele University, Via di Val Cannuta, 247, I-00166 Rome, Italy.
ORCID: 0000-0003-3833-6717

Daniela Merlo (D)

Department of Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299, I-00161 Rome, Italy.

Patrizia Russo (P)

Clinical and Molecular Epidemiology, IRCSS San Raffaele Pisana, Via di Val Cannuta, 247, I-00166 Rome, Italy.
Department of Human Sciences and Quality of Life Promotion San Raffaele University, Via di Val Cannuta, 247, I-00166 Rome, Italy.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Exopeptidases › Carboxypeptidases › Angiotensin-converting enzyme 2 › Nicotine Changes Airway Epithelial Phenotype...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Nicotine Changes Airway Epithelial Phenotype...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Nicotine Changes Airway Epithelial Phenotype...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Nicotine Changes Airway Epithelial Phenotype...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Nicotine Changes Airway Epithelial Phenotype...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Nicotine Changes Airway Epithelial Phenotype...
questionsmedicales.fr › Cellules › Cellules épithéliales › Nicotine Changes Airway Epithelial Phenotype...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Nicotine Changes Airway Epithelial Phenotype...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Nicotine › Nicotine Changes Airway Epithelial Phenotype...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs cholinergiques › Récepteurs nicotiniques › Nicotine Changes Airway Epithelial Phenotype...
questionsmedicales.fr › Appareil respiratoire › Nicotine Changes Airway Epithelial Phenotype...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Nicotine Changes Airway Epithelial Phenotype...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Enquêtes de santé › Indicateurs d'état de santé › Acuité des besoins du patient › Indice de gravité de la maladie › Nicotine Changes Airway Epithelial Phenotype...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Nicotine Changes Airway Epithelial Phenotype...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Fumer › Nicotine Changes Airway Epithelial Phenotype...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs cholinergiques › Récepteurs nicotiniques › Récepteur nicotinique de l'acétylcholine alpha7 › Nicotine Changes Airway Epithelial Phenotype...